TUMOR-LOCALIZATION OF THE METABOLICALLY TRAPPED RADIOLABELED SUBSTRATES 2-DEOXY-D-GLUCOSE AND AMINOCYCLOPENTANECARBOXYLIC ACID IN HUMAN-MELANOMA HETEROTRANSPLANTS
TUMOR-LOCALIZATION OF THE METABOLICALLY TRAPPED RADIOLABELED SUBSTRATES 2-DEOXY-D-GLUCOSE AND AMINOCYCLOPENTANECARBOXYLIC ACID IN HUMAN-MELANOMA HETEROTRANSPLANTS
复制标题
DOI：
10.1097/00000421-198612000-00014
复制
发表时间：
1986-12-01
影响因子：
2.6
通讯作者：
SCHMALL, B
中科院分区：
文献类型：
--
作者：
CONTI, PS;SORDILLO, PP;SCHMALL, B
利用正电子发射断层扫描(PET)技术分析放射性标记底物在正常组织和恶性肿瘤组织中的积聚，有助于研究体内的生物化学过程。如果用短命的、发射正电子的放射性核素碳-11(T1/2=20.4min)标记葡萄糖类似物2-脱氧-D-葡萄糖(2-DG)和合成氨基酸氨基环戊烷羧酸(ACPC)，则可用于研究葡萄糖在体内的利用和氨基酸转运。本研究评估了这些化合物的C-14标记类似物在荷人恶性黑色素瘤异种移植裸鼠体内的生物分布。数据表明，2-DG和ACPC均在45分钟内在肿瘤组织中积聚。
Analysis of the accumulation of metabolically trapped radiolabeled substrates in normal and malignant tissues may be useful for studying biochemical processes in vivo with positron emission tomography (PET). If labeled with the short-lived, positron-emitting radionuclide carbon-11 (T 1/2 = 20.4 min), the glucose analog, 2-deoxy-D-glucose (2-DG), and the synthetic amino acid, aminocyclopentanecarboxylic acid (ACPC), may be useful for studying glucose utilization and amino acid transport in vivo. This study evaluated the biodistribution of the C-14 labeled analogues of these compounds in nude mice bearing human malignant melanoma heterotransplants. The data suggest that both 2-DG and ACPC accumulate in tumor tissue within 45 min.