Alpha-human atrial natriuretic peptide is a coronary vasodilator in the Langendorff-perfused guinea pig heart.
Alpha-human atrial natriuretic peptide is a coronary vasodilator in the Langendorff-perfused guinea pig heart.
复制标题
α-人心房钠尿肽是 Langendorff 灌注豚鼠心脏中的冠状血管扩张剂。
DOI：
10.1016/0024-3205(88)90461-4
复制
发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Chimoskey,JE
中科院分区：
文献类型：
--
作者：
Otero,HO;Wangler,RD;Sparks,HV;Chimoskey,JE
循环形式的房利钠肽现在被认为是由28个氨基酸组成(1)。因此，我们研究了28个氨基酸的α-人心房钠肽（α-hANP）在5个离体豚鼠心脏恒压（46 mmHg）下的冠状动脉血管活性。通过注射去甲肾上腺素、腺苷和血管收缩心房利钠肽、心房肽II （APII）来保证每个心脏冠状动脉床的反应性。在这五颗心脏中，APII都是冠状动脉收缩因子。5个心脏注射19剂α-hANP，剂量范围为1.6 ~ 64 nmol/g湿心重。α-hANP在5颗心脏均为血管扩张剂。y=流量，%增加，x =剂量，nmol/g, isy= 17.98 logx−4.11的回归方程。相关系数r为0.83，决定系数r2为0.69。y和x回归方差分析的F统计量为36.9，P<0.00001。结果表明，在1.6 ~ 64 nmol/g范围内，α-hANP的剂量与冠状动脉血管舒张相关。
The circulating form of atrial natriuretic peptide is now believed to be composed of 28 amino acids (1). Therefore, we studied the coronary vasoactivity of the 28 amino acid, alpha-human atrial natriuretic peptide (α-hANP) in five isolated guinea pig hearts Langendorff-perfused at constant pressure (46 mmHg) with Krebs-Henseleit solution. The reactivity of the coronary bed was assured in each heart with bolus injections of norepinephrine, adenosine, and the vasoconstrictor atrial natriuretic peptide, atriopeptin II (APII). APII was a coronary constrictor in each of these five hearts. Nineteen boluses of α-hANP were administered to the five hearts, spanning the range 1.6 to 64 nmol/g wet heart weight. α-hANP was vasodilator in all five hearts. The equation for the regression of y = flow, % increase, on x = dose, nmol/g, isy= 17.98 logx −4.11. The correlation coefficient, r, is 0.83, and the coefficient of determination, r2, is 0.69. Analysis of variance of the regression of y and x yields an F statistic of 36.9, P<0.00001. These results indicate that coronary vasodilation is correlated with dose of α-hANP over much of the range 1.6 – 64 nmol/g.