Positron emission tomography in patients with breast cancer using 18F-3′-deoxy-3′-fluoro-L-thymidine (18F-FLT) -: a pilot study
Positron emission tomography in patients with breast cancer using 18F-3′-deoxy-3′-fluoro-L-thymidine (18F-FLT) -: a pilot study
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DOI：
10.1016/j.ejso.2005.09.011
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发表时间：
2006-02-01
期刊：
影响因子：
3.8
通讯作者：
Suurmeijer, AJH
中科院分区：
文献类型：
--
作者：
Been, LB;Elsinga, PH;Suurmeijer, AJH
Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla.Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.Conclusions: F-18-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases. (c) 2005 Elsevier Ltd. All rights reserved.
