Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families.
Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families.
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DOI：
10.1038/s41537-022-00317-w
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发表时间：
2022-11-25
期刊：
影响因子：
--
通讯作者：
Riley, Brien P.
中科院分区：
文献类型：
--
作者：
Ahangari, Mohammad;Kirkpatrick, Robert;Nguyen, Tan-Hoang;Gillespie, Nathan;Kendler, Kenneth S.;Bacanu, Silviu-Alin;Webb, Bradley T.;Verrelli, Brian C.;Riley, Brien P.
精神病和情感障碍通常聚集在精神分裂症先证者的亲属中，遗传研究表明精神分裂症、双相情感障碍和重度抑郁症之间存在显著的遗传相关性。在这项研究中，我们研究了双相情感障碍和重性抑郁症的多基因风险负担在257多重精神分裂症家庭（N = 1005）从爱尔兰研究的高密度多重精神分裂症家庭与2205个祖先匹配的控制。我们的研究结果表明，与对照人群相比，多重精神分裂症家族的成员患双相情感障碍和重性抑郁症的多基因风险增加。然而，这一观察结果在很大程度上归因于双相情感障碍或重性抑郁症与精神分裂症由于遗传相关性而共享的遗传风险部分，而不是它们特有的遗传风险的情感部分。这些研究结果表明，一个完整的解释交叉障碍多基因的风险，在多重家庭需要评估的相对贡献共享与独特的遗传因素，以解释跨精神疾病的遗传相关性。
Psychotic and affective disorders often aggregate in the relatives of probands with schizophrenia, and genetic studies show substantial genetic correlation among schizophrenia, bipolar disorder, and major depressive disorder. In this study, we examined the polygenic risk burden of bipolar disorder and major depressive disorder in 257 multiplex schizophrenia families (N = 1005) from the Irish Study of High-Density Multiplex Schizophrenia Families versus 2205 ancestry-matched controls. Our results indicate that members of multiplex schizophrenia families have an increased polygenic risk for bipolar disorder and major depressive disorder compared to population controls. However, this observation is largely attributable to the part of the genetic risk that bipolar disorder or major depressive disorder share with schizophrenia due to genetic correlation, rather than the affective portion of the genetic risk unique to them. These findings suggest that a complete interpretation of cross-disorder polygenic risks in multiplex families requires an assessment of the relative contribution of shared versus unique genetic factors to account for genetic correlations across psychiatric disorders.
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影响因子：
11
作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
通讯作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
30.8
作者：
Demange, Perline A.;Malanchini, Margherita;Nivard, Michel G.
通讯作者：
Nivard, Michel G.
影响因子：
25.8
作者：
Cheng, Weiqiu;Frei, Oleksandr;Andreassen, Ole A.
通讯作者：
Andreassen, Ole A.
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM