Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures.
Reduced proconvulsant activity of caffeine in rats after a series of electroconvulsive seizures.
复制标题
在一系列电惊厥发作后，咖啡因可降低大鼠的促惊厥活性。
DOI：
10.1007/bf02246060
复制
发表时间：
1995
影响因子：
3.4
通讯作者：
Fochtmann,L
中科院分区：
文献类型：
--
作者：
Francis,A;Fochtmann,L
大鼠电惊厥发作（ECS）后发生多种神经递质受体变化，包括腺苷A1位点密度增加。腺苷拮抗作用与甲基黄嘌呤如咖啡因的促惊厥作用有关。我们确定了紧张性阵挛发作持续时间的大鼠给予ECS与咖啡因（0-175 mg/kg，IP）后，一个或六个每日ECS的过程。一天的ECS没有影响咖啡因的剂量依赖性促惊厥作用。每天6次ECS后，咖啡因的促惊厥作用降低。每日9次ECS后，A1拮抗剂（8-环戊基-1，3-二丙基黄嘌呤）和A2 A拮抗剂（1-烯丙基-3，7-二甲基-8-对磺苯基黄嘌呤）的促惊厥活性降低。结果表明，慢性ECS后咖啡因的促惊厥作用减少依赖于腺苷拮抗作用。
A variety of neurotransmitter receptor changes occur after a course of electroconvulsive seizures (ECS) in rats, including an increased density of adenosine A1sites. Adenosine antagonism has been related to the proconvulsant action of methylxanthines such as caffeine. We determined tonic-clonic seizure duration in rats given ECS with caffeine (0–175 mg/kg, IP) after a course of one or six daily ECS. A single day of ECS did not affect the dose-dependent proconvulsant action of caffeine. After six daily ECS, the proconvulsant action of caffeine was reduced. After nine daily ECS, an A1antagonist (8-cyclopentyl-1,3-dipropylxanthine) and an A2Aantagonist (1-allyl-3,7-dimethyl-8-p-sulfophenylxanthine) showed reduced proconvulsant activity. The results suggest that the reduced proconvulsant action of caffeine after chronic ECS depends on adenosine antagonism.