The Relationship between Anxiety Sensitivity and Posttraumatic Stress Disorder: What is the Impact of Nicotine Withdrawal?
The Relationship between Anxiety Sensitivity and Posttraumatic Stress Disorder: What is the Impact of Nicotine Withdrawal?
复制标题
焦虑敏感性与创伤后应激障碍之间的关系：尼古丁戒断有何影响？
DOI：
10.1007/s10608-015-9685-5
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发表时间：
2015
影响因子：
2.8
通讯作者：
Foa,EdnaB
中科院分区：
文献类型：
--
作者：
Asnaani,Anu;Farris,SamanthaG;Carpenter,JosephK;Zandberg,LaurieJ;Foa,EdnaB
焦虑敏感性（AS）与吸烟者创伤后应激障碍（PTSD）的发展和维持有关，也与急性尼古丁戒断症状的放大有关。本研究旨在探讨尼古丁戒断在缓解AS和PTSD症状严重程度之间的相关性中的作用，其中一个寻求治疗的PTSD吸烟者样本。参与者（n = 117）参加了一项治疗PTSD和尼古丁依赖的随机对照试验。横断面数据从三个不同的研究时间点随机抽样。一系列的多元回归模型进行了测试。结果显示，在控制了性别、评估时间点、负性情感和生化验证的吸烟（过期一氧化碳）后，AS和戒断严重程度对PTSD严重程度的主要影响。AS和戒断的相互作用也很显著，似乎是特定于PTSD回避和过度觉醒症状。然而，与预期相反，AS和PTSD症状之间的关联仅在尼古丁戒断水平相对较低时才显着。这些发现强调了AS、尼古丁戒断以及它们在PTSD病理学恶化方面的协同作用之间的复杂相互作用。
Anxiety sensitivity (AS) is related to the development and maintenance of posttraumatic stress disorder (PTSD) among cigarette smokers, and is also implicated in the amplification of acute nicotine withdrawal symptoms. The present study sought to examine the role of nicotine withdrawal in moderating the association between AS and PTSD symptom severity among a sample of treatment-seeking smokers with PTSD. Participants (n = 117) were enrolled in a randomized controlled trial for the treatment of PTSD and nicotine dependence. Cross-sectional data were randomly sampled from three different study time points. A series of multiple regression models were tested. Results revealed main effects of both AS and withdrawal severity on PTSD severity after controlling for gender, assessment time-point, negative affectivity, and biochemically verified smoking (expired carbon monoxide). The interaction of AS and withdrawal was also significant, and appeared to be specific to PTSD avoidance and hyperarousal symptoms. However, contrary to expectations, the association between AS and PTSD symptoms was only significant at relatively lower levels of nicotine withdrawal. These findings highlight the complex interplay between AS, nicotine withdrawal, and their synergistic effect in terms of the exacerbation of PTSD symptomology.