The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation.
The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation.
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DOI：
10.3389/fimmu.2014.00317
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发表时间：
2014
影响因子：
7.3
通讯作者：
Cominelli F
中科院分区：
文献类型：
--
作者：
Corridoni D;Arseneau KO;Cifone MG;Cominelli F
核苷酸结合和寡聚化结构域NOD样受体（NLR）是高度保守的胞质模式识别受体，其与Toll样受体组合在先天免疫和炎症中起关键作用。这些蛋白质的特征在于被称为核苷酸结合结构域的中心寡聚化结构域和含有富含亮氨酸的重复序列的蛋白质相互作用结构域。一些NLR，包括NOD 1和NOD 2，感知保守细菌分子特征的胞质存在，并驱动促分裂原活化蛋白激酶和转录因子NF-κB的活化。一组不同的NLR通过组装称为炎性小体的大蛋白复合物诱导半胱天冬酶-1活化。NLR蛋白的活化导致促炎细胞因子的分泌和随后的炎症反应。NLR在先天免疫中的关键作用通过其基因内的多态性与几种免疫介导的疾病（包括炎性肠病）的发展有关的事实来强调。在过去的几年中，NLR在肠道内稳态中的作用已经被强调，然而这些蛋白质的功能障碍导致异常炎症的机制仍然是许多研究的焦点。本综述的目的是系统地评价NLR在粘膜先天免疫中的功能，并了解这些成分的遗传或功能改变如何导致肠道稳态的破坏，以及随后的慢性炎症的发展。
Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly conserved cytosolic pattern recognition receptors that play, in combination with toll-like receptors, a critical role in innate immunity and inflammation. These proteins are characterized by a central oligomerization domain termed nucleotide-binding domain, and a protein interaction domain containing leucine-rich repeats. Some NLRs, including NOD1 and NOD2, sense the cytosolic presence of conserved bacterial molecular signatures and drive the activation of mitogen-activated protein kinase and the transcription factor NF-κB. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes known as inflammasomes. Activation of NLR proteins results in secretion of pro-inflammatory cytokines and subsequent inflammatory responses. The critical role of NLRs in innate immunity is underscored by the fact that polymorphisms within their genes are implicated in the development of several immune-mediated diseases, including inflammatory bowel disease. Over the past few years, the role of NLRs in intestinal homeostasis has been highlighted, however the mechanism by which dysfunction in these proteins leads to aberrant inflammation is still the focus of much investigation. The purpose of this review is to systematically evaluate the function of NLRs in mucosal innate immunity and understand how genetic or functional alterations in these components can lead to the disruption of intestinal homeostasis, and the subsequent development of chronic inflammation.
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影响因子：
7.8
作者：
Barnich, N;Aguirre, JE;Podolsky, DK
通讯作者：
Podolsky, DK
影响因子：
24.5
作者：
Bauer, Christian;Duewell, Peter;Schnurr, Max
通讯作者：
Schnurr, Max
影响因子：
64.8
作者：
Bouskra, Djahida;Brezillon, Christophe;Eberl, Gerard
通讯作者：
Eberl, Gerard
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
影响因子：
3.7
作者：
Allen IC;McElvania-TeKippe E;Wilson JE;Lich JD;Arthur JC;Sullivan JT;Braunstein M;Ting JP
通讯作者：
Ting JP