The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.

The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.
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DOI:
10.3390/ijms22042170
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发表时间:
2021-02-22
影响因子:
5.6
通讯作者:
Pieta W
Pieta W
中科院分区:
生物学2区
文献类型:
--
作者:
Smolarczyk K;Mlynarczyk-Bonikowska B;Rudnicka E;Szukiewicz D;Meczekalski B;Smolarczyk R;Pieta W

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淋球菌、沙眼衣原体和生殖支原体引起的性传播感染(STI)是导致输卵管因素不孕症(TFI)的盆腔炎(PID)的常见原因。TFI是导致不孕的最常见原因之一,占女性生育问题的30%。性传播感染也可能对怀孕产生影响,导致不良妊娠结局。淋病奈瑟菌和生殖支原体对抗生素耐药性的上升是一个重大问题,在治疗上可能具有挑战性。我们对目前的治疗方案以及分子方法进行了全面的回顾。我们特别关注分子流行病学、分子诊断学、当前和新的治疗方法以及耐药性。
Sexually transmitted infections (STIs) caused by Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium are a common cause of pelvic inflammatory disease (PID) which can lead to tubal factor infertility (TFI). TFI is one of the most common causes of infertility, accounting for 30% of female fertility problems. STIs can also have an impact on pregnancy, leading to adverse pregnancy outcomes. Escalating antibiotic resistance in Neisseria gonorrhoeae and Mycoplasma genitalium represents a significant problem and can be therapeutically challenging. We present a comprehensive review of the current treatment options, as well as the molecular approach to this subject. We have given special attention to molecular epidemiology, molecular diagnostics, current and new treatments, and drug resistance.
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