ACUTE AND CHRONIC SYSTEMIC CHROMIUM TOXICITY
ACUTE AND CHRONIC SYSTEMIC CHROMIUM TOXICITY
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DOI：
10.1016/0048-9697(89)90201-5
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发表时间：
1989-10-01
影响因子：
9.8
通讯作者：
GAD, SC
中科院分区：
文献类型：
--
作者：
GAD, SC
虽然160多年来，铬及其化合物一直被认为对健康具有潜在的严重不良影响，但对这些化合物的系统毒理学和真正的危害的了解仍然不完整。本文综述了铬化合物的研究现状，特别是六价铬化合物是致癌物质、腐蚀剂、延迟接触增敏剂，并以肾脏为主要靶器官。但铬也是人体必需的元素。人体显然有一些有效的解毒机制，可以在一定程度上接触到六价铬化合物。鉴于这些考虑，提出了急性和慢性铬毒性的显著特征。
Although chromium and compounds containing it have been recognized as having potential severe adverse effects on health for more than 160 years, understanding of the systemic toxicology and true hazard of these compounds is still not complete. A review of the current state of knowledge is attempted in this paper, with appropriate attention given to the complications of multiple valence states and solubility.Selected chromium compounds, particularly hexavalent ones, are carcinogens, corrosives, delayed contact sensitizers, and have the kidney as their primary target organ. But chromium is also an essential element for humans. The body clearly possesses some effective detoxification mechanisms for some degree of exposure to hexavalent chrome compounds. The significant features of acute and chronic chromium toxicity are presented in view of these considerations.