Prevalence and epidemiology of hepatitis D among patients with chronic hepatitis B virus infection: a report from Northern Spain
Prevalence and epidemiology of hepatitis D among patients with chronic hepatitis B virus infection: a report from Northern Spain
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DOI：
10.1097/meg.0000000000000795
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发表时间：
2017-03-01
影响因子：
2.1
通讯作者：
Rodriguez, Manuel
中科院分区：
文献类型：
--
作者：
Ordieres, Carlos;Navascues, Carmen A.;Rodriguez, Manuel
背景在过去的几十年中，丁型肝炎病毒（HDV）感染的发病率有所下降。然而，一个不断增长的趋势已被报道recently.Patients和方法我们进行了一项病例对照研究，分析其患病率的变化，在1215慢性肝炎B病毒（HBV）患者，连续诊断在三级中心，1983年和2012年之间。结果抗HDV阳性率为8.2%，其中A组为9.4%，B组为6.1%（P=0.04）。多因素回归分析显示静脉吸毒[比值比（OR）261.0; 95%可信区间（CI）28.7-2368.5; P
Background The incidence of hepatitis delta virus (HDV) infection has decreased during the last decades. However, an increasing trend has been reported recently.Patients and methods We carried out a case-control study to analyze changes in its prevalence in 1215 chronic hepatitis B virus (HBV) patients, diagnosed consecutively in a tertiary center, between 1983 and 2012. According to the year of diagnosis, patients were distributed into two groups: A [1983-1997 (n=786)] and B [1998-2012 (n = 429)].Results The prevalence of anti-HDV was 8.2% (9.4% in group A and 6.1% in group B) (P=0.04). Multivariate regression revealed that intravenous drug use [odds ratio (OR) 261.0; 95% confidence interval (CI), 28.7-2368.5; P