Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women
Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women
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DOI：
10.1210/jc.2010-0181
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Lin, Xu
中科院分区：
文献类型：
--
作者：
Wu, Hongyu;Qi, Qibin;Lin, Xu
目的：目的是调查中国人群中局部脂肪库与脂肪因子、炎症标志物和代谢综合征 (MetS) 风险的关联。 设计和方法：通过全身双能 X 射线骨密度扫描，对 1150 名 50-70 岁中国人（479 名男性和 671 名女性）样本中的躯干和腿部脂肪量进行测定。测定血浆脂联素、纤溶酶原激活物抑制剂-1 (PAI-1)、视黄醇结合蛋白 4 (RBP4)、抵抗素、C 反应蛋白和 IL-6。更新后的国家胆固醇教育计划成人治疗小组 III 针对亚裔美国人的标准用于定义 MetS。结果：无论男女，较大的体型调整躯干脂肪量均与较低的脂联素和较高的 PAI-1、RBP4、C 反应蛋白和 IL-6 水平显着相关（P < 0.05）。较大的体型调整腿部脂肪量与男性和女性较高的脂联素水平显着相关，但与男性较低的 RBP4 和 PAI-1 浓度相关（P < 0.05）。与最低体型调整腿部脂肪质量三分位数相比，最高三分位数中 MetS 的比值比（95% 置信区间）男性为 0.33（0.18-0.62；趋势 P < 0.001），女性为 0.43（0.28-0.65；趋势 P < 0.001）。随着进一步控制脂肪因子和炎症标志物，这种关联性减弱（男性 P = 0.09，女性 P = 0.004）。结论：与躯干脂肪相比，大腿部脂肪似乎对中国人的脂肪因子、炎症标志物和 MetS 风险具有有利影响。区域脂肪库和 MetS 风险之间相反的关联可能部分是由脂肪因子和炎症状态介导的。 （临床内分泌代谢杂志 95：4389-4398，2010）
Objective: The objective was to investigate associations of regional fat depots with adipokines, inflammatory markers, and risk of metabolic syndrome (MetS) in a Chinese population.Design and Methods: Trunk and leg fat mass were determined in a population-based sample of 1150 Chinese (479 men and 671 women) aged 50-70 yr by using whole-body dual-energy x-ray absorptiometry scan. Plasma adiponectin, plasminogen activator inhibitor-1 (PAI-1), retinol-binding protein 4 (RBP4), resistin, C-reactive protein, and IL-6 were measured. The updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans was used to define MetS.Results: Larger body-size adjusted trunk fat mass was significantly associated with lower adiponectin and higher PAI-1, RBP4, C-reactive protein, and IL-6 levels in both genders (P < 0.05). Larger body-size adjusted leg fat mass was significantly associated with higher adiponectin levels in both genders but lower RBP4 and PAI-1 concentrations in men (P < 0.05). Comparing with the lowest body-size adjusted leg fat mass tertile, the odds ratio (95% confidence interval) of MetS in the highest tertile was 0.33 (0.18-0.62; P for trend < 0.001) for men and 0.43 (0.28-0.65; P for trend < 0.001) for women. The association was attenuated with further controlling adipokines and inflammatory markers (P = 0.09 for men and P = 0.004 for women).Conclusion: In contrast to trunk fat, large leg fat appears to have favorable effects on adipokines, inflammatory markers, and MetS risk among Chinese. The opposite associations between regional fat depots and MetS risk may partially mediated by adipokines and inflammatory status. (J Clin Endocrinol Metab 95: 4389-4398, 2010)