TETRAGLYCYLFERRICHROME - THE 1ST HEPTAPEPTIDE FERRICHROME
TETRAGLYCYLFERRICHROME - THE 1ST HEPTAPEPTIDE FERRICHROME
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DOI：
10.1016/0014-5793(84)81016-9
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发表时间：
1984-01-01
期刊：
影响因子：
3.5
通讯作者：
WINKELMANN, G
中科院分区：
文献类型：
--
作者：
DEML, G;VOGES, K;WINKELMANN, G
从一株印度新伏菌Neovossia indien（Mitra）Mundk.一种黑粉菌目的腥黑粉菌，分离出一种新的铁色素型铁载体。我们已经证明，这是一个七肽，而不是通常的六肽，其中含有，除了L-鸟氨酸，（Gly）4序列，而不是（Gly）3序列通常发现。运输研究与55铁标记的（Gly）4-ferrichrome和（Gly）3-ferrichrome在粗糙脉孢菌显示相同的吸收率，表明在铁色素转运系统的功能和识别过程中，肽骨架的环尺寸和构象柔性的增加是次要的。
From a strain ofNeovossia indien(Mitra) Mundk., a smut fungus of the order Tilletiales, a novel ferrichrome‐type siderophore was isolated. We have demonstrated that this is a heptapeptide rather than the usual hexapeptide, which contained, in addition to L‐ornithine, a (Gly)4sequence instead of the (Gly)3sequence usually found. Transport studies with55Fe‐labelled (Gly)4‐ferrichrome and (Gly)3‐ferrichrome inNeurospora crassarevealed identical uptake rates, indicating that increased ring size and conformational flexibility of the peptide backbone are of minor importance during function and recognition by the ferrichrome transport system.