Use of liposomes in treating type II glycogenosis.
Use of liposomes in treating type II glycogenosis.
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脂质体在治疗 II 型糖原增多症中的用途。
DOI：
10.1136/bmj.2.6027.88
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发表时间：
1976
影响因子：
--
通讯作者：
V. Dubowitz
中科院分区：
文献类型：
--
作者：
D. Tyrrell;B. E. Ryman;B. Keeton;V. Dubowitz
我们的研究结果表明，克罗恩病患者的T细胞功能低下。值得注意的是，我们在克罗恩病中的PHA刺激试验值介于正常值和本实验室发现的霍奇金病严重降低值之间（1117 + 476 cpm/1000淋巴细胞; n = 6）。5尽管霍奇金病患者对真菌和病毒感染的易感性增加，但克罗恩病的情况并非如此。在我们的患者中发现的T细胞功能的不太严重的抑制可能与对这些感染的相对免疫有关。营养不良可能导致T细胞功能异常。所有患者血清白蛋白水平均未低于31 g/L，平均水平为40.3g/L。平均血红蛋白水平为13.8 g/dl，无水平低于11.1 g/dl。叶酸缺乏也会导致PHA反应降低。我们所有的患者都具有正常的红细胞叶酸水平（> 160.Lg/l红细胞）。我们已经显示出给予转移因子后对PHA刺激的反应有显著改善。我们的三个病人也显示他们的结核菌素试验结果的转换。这项研究提出的问题之一是T细胞异常在克罗恩病中的意义。T细胞异常可能与疾病有因果关系，也可能只是一种附带现象。为了解决这一问题，同时也为了研究转移因子的治疗作用，这将是一个新的课题。有必要进行长期对照试验。
Our results show that patients with Crohn's disease have depressed T-cell function. It is interesting to note that our values for the PHA stimulation test in Crohn's disease were intermediate between normal values and the severely depressed values of Hodgkin's disease found in this laboratory (1117 +476 cpm/1000 lymphocytes; n = 6).5 Although patients with Hodgkin's disease have increased susceptibility to fungal and viral infections, this is not the case in Crohn's disease. The less severe depression of T-cell function found in our patients may be related to this relative immunity to those infections. Malnutrition may cause abnormalities of T-cell function. None of our patients had a serum albumin level under 31 g/l, and the mean level was 40 3 g/l. The mean haemoglobin level was 13 8 g/dl with no level below 11-1 g/dl. Folate deficiency can also cause a lowered PHA response. All our patients had normal red cell folate levels (> 160 .Lg/l of red cells). We have shown a significant improvement in the response to PHA stimulation after giving transfer factor. Three of our patients also showed conversion of their tuberculin test results. One of the questions that this study raises is the significance of T-cell abnormalities in Crohn's disease. The T-cell abnormalities may be causally linked with the disease or may just be an epiphenomenon. To resolve this question and also to study the therapeutic effect of transfer factor it wil! be necessary to carry out long-term controlled trials.