Integration deficiencies associated with continuous limb movement sequences in Parkinson's disease.
Integration deficiencies associated with continuous limb movement sequences in Parkinson's disease.
复制标题
帕金森病中与连续肢体运动序列相关的整合缺陷。
DOI：
10.1016/j.parkreldis.2009.04.001
复制
发表时间：
2009
影响因子：
4.1
通讯作者：
Stelmach,GeorgeE
中科院分区：
文献类型：
--
作者：
Park,Jin-Hoon;Stelmach,GeorgeE
The present study examined the extent to which Parkinson's disease (PD) influences integration of continuous limb movement sequences. Eight patients with idiopathic PD and 8 age-matched normal subjects were instructed to perform repetitive sequential aiming movements to specified targets under three-accuracy constraints: 1) low accuracy (W = 7 cm) – minimal accuracy constraint, 2) high accuracy (W = 0.64 cm) – maximum accuracy constraint, and 3) mixed accuracy constraint – one target of high accuracy and another target of low accuracy. The characteristic of sequential movements in the low accuracy condition was mostly cyclical, whereas in the high accuracy condition it was discrete in both groups. When the accuracy constraint was mixed, the sequential movements were executed by assembling discrete and cyclical movements in both groups, suggesting that for PD patients the capability to combine discrete and cyclical movements to meet a task requirement appears to be intact. However, such functional linkage was not as pronounced as was in normal subjects. Close examination of movement from the mixed accuracy condition revealed marked movement hesitations in the vicinity of the large target in PD patients, resulting in a bias toward discrete movement. These results suggest that PD patients may have deficits in ongoing planning and organizing processes during movement execution when the tasks require to assemble various accuracy requirements into more complex movement sequences.
