Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly
Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly
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DOI：
10.1039/c5py01609f
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发表时间：
2016-01-01
影响因子：
4.6
通讯作者：
Klumperman, Bert
中科院分区：
文献类型：
--
作者：
Giliomee, Johnel;Pfukwa, Rueben;Klumperman, Bert
通过 RAFT 介导的聚合很容易合成生物相容性聚（3-乙基-N-乙烯基吡咯烷酮）和聚（N-乙烯基吡咯烷酮）的刺激响应嵌段共聚物，即 EPVP-PVP。使用各种光谱和显微镜技术研究了水溶液中的热响应行为和温度诱导的自组装。我们获得了不同的形态，即。 e.通过简单地调节溶液浓度，通过温度诱导的单一二嵌段共聚物水溶液的自组装，形成球形和圆柱形胶束和囊泡。本研究将生物相容性 EPVP/PVP 组合确立为适合药物输送应用的多功能刺激响应嵌段共聚物系统。
Stimuli responsive block copolymers of biocompatible poly(3-ethyl-N-vinylpyrrolidone) and poly(N-vinylpyrrolidone), i.e. EPVP-PVP, were readily synthesized via RAFT-mediated polymerization. The thermoresponsive behaviour and temperature induced self-assembly, in aqueous solutions, was studied using various spectroscopic and microscopy techniques. We obtained different morphologies, i. e. spherical and cylindrical micelles, and vesicles, via temperature induced self-assembly, of aqueous solutions of a single diblock copolymer by simply adjusting the solution concentration. This study establishes the biocompatible EPVP/PVP combination as a versatile stimuli responsive block copolymer system suitable for applications in drug delivery.