Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
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DOI：
10.1016/s0002-9343(99)00066-2
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发表时间：
1999-05-01
影响因子：
5.9
通讯作者：
Wallace, R
中科院分区：
文献类型：
--
作者：
Harris, TB;Ferrucci, L;Wallace, R
目得：调查白细胞介素-6和C-反应蛋白水平是否预测所有原因和原因特异性死亡率在一个以人口为基础的样本nondisabled elderly people.SUBJECTS和METHODS：一个样本的1,293名健康，nondisabled参与者在爱荷华州65+农村健康研究进行了前瞻性随访，平均为4.6年。从1987年至1989年收集的标本中检测血浆白细胞介素-6和C反应蛋白水平。结果：白细胞介素-6水平升高与死亡风险增加2倍[相对风险（RR）最高四分位数（≥ 3.19 pg/mL）与最低四分位数1.9 [95%可信区间，CI，1.2至3.11]。较高的C反应蛋白水平（大于或等于2.78 mg/L）也与风险增加相关（RR = 1.6; CI，1.0至2.6）。白细胞介素-6和C反应蛋白水平均升高的受试者在随访期间死亡的可能性是两种测量值均低的受试者的2.6倍（CI，1.6至4.3）。心血管和非心血管死亡原因的结果相似，当受试者按性别、吸烟状况和既往心血管疾病分层时，
PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people.SUBJECTS AND METHODS: A sample of 1,293 healthy, nondisabled participants in the Iowa 65+ Rural Health Study was followed prospectively for a mean of 4.6 years. Plasma interleukin-6 and C-reactive protein levels were measured in specimens obtained from 1987 to 1989.RESULTS: Higher interleukin-6 levels were associated with a twofold greater risk of death [relative risk (RR) for the highest quartile (greater than or equal to 3.19 pg/mL) compared with the lowest quartile of 1.9 [95% confidence interval, CI, 1.2 to 3.11]. Higher C-reactive protein levels (greater than or equal to 2.78 mg/L) were also associated with increased risk (RR = 1.6; CI, 1.0 to 2.6). Subjects with elevation of both interleukin-6 and C-reactive protein levels were 2.6 times more likely (CI, 1.6 to 4.3) to die during follow-up than those with low levels of both measurements. Similar results were found for cardiovascular and noncardiovascular causes of death, as well as when subjects were stratified by sex, smoking status, and prior cardiovascular disease, and for both early (