A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: a retrospective survival analysis
A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: a retrospective survival analysis
复制标题
DOI：
10.1097/ypg.0b013e32833a1f0e
复制
发表时间：
2010-08-01
影响因子：
0.9
通讯作者：
Murata, Shiho
中科院分区：
文献类型：
--
作者：
Ando, Tetsuya;Komaki, Gen;Murata, Shiho
背景神经性厌食症限制型（AN-R）患者常出现暴食症状，并可转变为AN暴食/泻出型（AN-BP）或神经性贪食症（BN）。我们之前已经报道了食欲肽ghrelin的遗传变异与BN相关。在这里，生长激素释放肽基因变异和变化率从AN-R到其他表型的进食障碍（EDs.Methods）之间的关系进行了调查165例艾德，最初诊断为AN-R。回顾性分析AN-R的发病日期及向其他艾德亚型的转变。Ghrelin基因3056 T-C SNP（单核苷酸多态性）基因分型。使用寿命表分析和考克斯比例风险回归模型分析概率和风险比，其中起点是AN-R发作的时间，结局事件是（i）开始暴饮暴食的时间，即患者变为暴饮暴食AN和BN的时间，以及（ii）恢复正常体重的时间，即，结果3056 T-C位点TT基因型患者体重恢复正常的概率和风险比均较高。结论Ghrelin基因3056 T-C SNP与限制型AN患者体重恢复的概率及恢复率有关。Psychiatr Genet 20：153-159（C）2010 Wolters Kluwer Health|利平科特威廉姆斯&威尔金斯。
Background Patients with anorexia nervosa restricting type (AN-R) often develop bulimic symptoms and crossover to AN-binge eating/purging type (AN-BP), or to bulimia nervosa (BN). We have reported earlier that genetic variants of an orexigenic peptide ghrelin are associated with BN. Here, the relationship between a ghrelin gene variant and the rate of change from AN-R to other phenotypes of eating disorders (EDs) was investigated.Methods Participants were 165 patients with ED, initially diagnosed as AN-R. The dates of their AN-R onset and changes in diagnosis to other subtypes of ED were investigated retrospectively. Ghrelin gene 3056 T-C SNP (single nucleotide polymorphism) was genotyped. Probability and hazard ratios were analyzed using life table analysis and Cox's proportional hazard regression model, in which the starting point was the time of AN-R onset and the outcome events were the time of (i) onset of binge eating, that is, when patients changed to binge eating AN and BN and (ii) recovery of normal weight, that is, when patients changed to BN or remission.Results Patients with the TT genotype at 3056 T-C had a higher probability and hazard ratio for recovery of normal weight. The ghrelin SNP was not related with the onset of binge eating.Conclusion The 3056 T-C SNP of the ghrelin gene is related to the probability and the rate of recovery of normal body weight from restricting-type AN. Psychiatr Genet 20: 153-159 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.