Plasma Homocysteine, Serum Folic Acid, Serum Vitamin B12, Serum Vitamin B6, MTHFR, and Risk of Normal-Tension Glaucoma
Plasma Homocysteine, Serum Folic Acid, Serum Vitamin B12, Serum Vitamin B6, MTHFR, and Risk of Normal-Tension Glaucoma
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DOI：
10.1097/ijg.0000000000000269
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发表时间：
2016-02-01
影响因子：
2
通讯作者：
Lan, Yuqing
中科院分区：
文献类型：
--
作者：
Li, Jinmiao;Xu, Fan;Lan, Yuqing
背景：本荟萃分析旨在全面评估总同型半胱氨酸（tHcy）水平、血清叶酸、维生素B-12、维生素B-6水平、亚甲基四氢叶酸还原酶（MTHFR） C677T基因型与正常张力青光眼（NTG）风险之间的关系。材料和方法：系统检索EMBASE和PubMed数据库，评估病例和对照组之间MTHFR C677T基因型的血浆tHcy水平、血清叶酸、B族维生素的平均差异和优势比。结果：本meta分析共纳入7项研究，包括458例病例和555例对照，符合纳入标准。有4项研究针对tHcy（149例，148例对照），2项研究针对维生素B-6、维生素B-12和叶酸（90例，82例对照），4项研究针对MTHFR（343例，449例对照）。总体而言，平均血浆tHcy水平，血清叶酸，维生素B-12和维生素B-6水平为1.16 μ mol/L[95%置信区间（CI）， -0.13, 2.45], -0.62 μ mol/L (95% CI, -1.98, 0.74), 5.81 μ mol/L （95% CI, -3.53, 15.14）和-16.79 μ mol/L （95% CI, -86.09, 52.51）。发现MTHFR TT基因型与NTG风险无关（优势比= 1.08;95% CI, 0.69, 1.69）。结论：NTG与血浆tHcy、血清叶酸、血清维生素B-12、血清维生素B-6和MTHFR C677T基因型升高无关。
Background: This meta-analysis aims to comprehensively evaluate the association between total homocysteine (tHcy) levels, serum folic acid, vitamin B-12, vitamin B-6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, and risk of normal-tension glaucoma (NTG).Materials and Methods: A systematic search of the EMBASE and PubMed databases was performed to evaluate plasma tHcy levels, serum folic acid, B vitamins' mean difference, and odds ratios of MTHFR C677T genotype between cases and controls.Results: A total of 7 studies including 458 cases and 555 controls meeting the inclusion criteria were involved in this meta-analysis. There were 4 studies for tHcy (149 cases and 148 controls), 2 studies for vitamin B-6, vitamin B-12, and folate (90 cases and 82 controls), and 4 studies for MTHFR (343 cases and 449 controls). Overall, the mean plasma tHcy levels, serum folic acids, vitamin B-12, and vitamin B-6 levels were 1.16 mu mol/L [95% confidence interval (CI), -0.13, 2.45], -0.62 mu mol/L (95% CI, -1.98, 0.74), 5.81 mu mol/L (95% CI, -3.53, 15.14), and -16.79 mu mol/L (95% CI, -86.09, 52.51). MTHFR TT genotype was found to be unrelated to NTG risk (odds ratio = 1.08; 95% CI, 0.69, 1.69).Conclusion: NTG is not associated with elevated plasma tHcy, serum folic acid, serum vitamin B-12, serum vitamin B-6, and MTHFR C677T genotype.