Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia
Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia
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DOI：
10.1016/j.schres.2008.01.017
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Suzuki, Hidenori
中科院分区：
文献类型：
--
作者：
Ikeda, Yumiko;Yahata, Noriaki;Suzuki, Hidenori
神经营养因子（NFS）在中枢神经系统的发展中起关键作用。因此，他们还涉嫌参与精神分裂症的病因。先前的研究报道，精神分裂症中血清脑衍生的神经营养因子（BDNF）的水平降低，而表皮生长因子（EGF）与这种疾病的关联仍然存在争议。我们使用两位酶免疫测定法，在一组慢性精神分裂症患者（n = 74）和一组正常对照组中，同时进行了血清BDNF和EGF水平的同时测量。 （n = 8 7）。我们发现，与正常对照组相比，慢性精神分裂症患者在检查的所有年龄段（21 - 59年）中表现出较低的BDNF和EGF血清水平。 BDNF和EGF的血清水平在对照组中呈负相关（r = -0.387，p = 0.0002），但在患者中不相关。诸如疾病持续时间和精神病量表之类的临床参数也与NF水平没有牢固的相关性。总的来说，这些结果表明，NF的普遍，异常信号传导是慢性精神分裂症的病理生理学的基础。 （c）2008 Elsevier B.V.保留所有权利。
Neurotrophic factors (NFs) play a pivotal role in the development of the central nervous system. They are thus also suspected of being involved in the etiology of schizophrenia. Previous studies reported a decreased level of serum brain-derived neurotrophic factor (BDNF) in schizophrenia, whereas the association of epidermal growth factor (EGF) with this illness remains controversial. Using a two-site enzyme immunoassay, we conducted the simultaneous measurement of serum BDNF and EGF levels in a group of patients with chronic schizophrenia (N= 74) and a group of normal controls matched in age, body mass index, smoking habit and sex (N= 8 7). We found that, compared to normal controls, patients with chronic schizophrenia exhibited lower serum levels of both BDNF and EGF across all ages examined (21-59 years). The serum levels of BDNF and EGF were negatively correlated in the controls (r=-0.387, P=0.0002) but not in the patients. Clinical parameters such as duration of illness and psychiatric rating scale also showed no robust correlations with the NF levels. Collectively, these results suggest that pervasive, abnormal signaling of NFs underlies the pathophysiology of chronic schizophrenia. (C) 2008 Elsevier B.V. All rights reserved.