Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research
Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research
复制标题
DOI：
10.1089/jwh.2012.3789
复制
发表时间：
2012-10-01
影响因子：
3.5
通讯作者：
Kalbarczyk, Anna
中科院分区：
文献类型：
--
作者：
Carter, Christine L.;Resnick, Eileen M.;Kalbarczyk, Anna
阿尔茨海默病(AD)在患病率和严重程度上对女性的影响都不成比例；然而，这些性别差异背后的生物机制尚未完全了解。大脑中的性别差异，如脑解剖、与年龄相关的脑体积下降和脑葡萄糖代谢，已经被记录在案，这可能对理解AD的病因很重要。性别作为一种基本的生物变量对这种神经退行性疾病的全面影响仍然难以捉摸。为了解决阿尔茨海默病性别差异的证据，妇女健康研究学会(SWHR)召集了一个由来自学术界、临床医学、工业界和政府的专家组成的跨学科圆桌会议，讨论AD性别和性别差异的最新科学状况。圆桌会议参与者被要求解决我们知识中的差距，并为未来的研究领域确定具体的基于性别的研究问题。
Alzheimer's disease (AD) disproportionately affects women in both prevalence and severity; however, the biologic mechanisms underlying these sex differences are not fully understood. Sex differences in the brain, such as in brain anatomy, age-related declines in brain volume, and brain glucose metabolism, have been documented and may be important in understanding AD etiology. The full impact of sex as a basic biologic variable on this neurodegenerative disease remains elusive. To address the evidence for sex differences in AD, the Society for Women's Health Research (SWHR) convened an interdisciplinary roundtable of experts from academia, clinical medicine, industry, and the government to discuss the state-of-the-science in sex and gender differences in AD. Roundtable participants were asked to address gaps in our knowledge and identify specific sex-based research questions for future areas of study.