Sleep Patterns in Late Pregnancy and Risk of Preterm Birth and Fetal Growth Restriction
Sleep Patterns in Late Pregnancy and Risk of Preterm Birth and Fetal Growth Restriction
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DOI：
10.1097/ede.0b013e31822546fd
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发表时间：
2011-09-01
期刊：
影响因子：
5.4
通讯作者：
Chatzi, Leda
中科院分区：
文献类型：
--
作者：
Micheli, Katerina;Komninos, Ioannis;Chatzi, Leda
背景资料：在怀孕期间，由于怀孕的生理和激素变化，妇女特别容易睡眠不足和打鼾。关于怀孕期间的睡眠模式与不良出生结果之间的联系，证据有限。我们研究了睡眠时间和打鼾在怀孕后期与早产和胎儿生长受限的风险的关联：我们使用的数据从前瞻性的母亲-儿童队列研究“瑞亚”在克里特岛，希腊2007-2009年。该分析包括1091名单胎妊娠妇女，提供了妊娠晚期睡眠习惯和分娩结局的完整数据。胎儿生长受限是基于一个定制的模型，多变量对数二项回归模型用于调整混杂因素。打鼾严重的妇女是低出生体重的高危人群（相对风险= 2.6 [95%置信区间= 1.2-5.4]），和胎儿生长受限的新生儿（2.0 [1.0-3.9]）校正母亲年龄、教育、孕期吸烟和孕前体重指数（BMI）后。睡眠不足的女性（
Background: During pregnancy, women are at particular risk for sleep deprivation and snoring because of the physiologic and hormonal changes of pregnancy. There is limited evidence for the association between sleep patterns in pregnancy and adverse birth outcomes. We examined the association of sleep duration and snoring in late pregnancy with the risk of preterm birth and fetal growth restriction.Methods: We used data from the prospective mother-child cohort "Rhea" study in Crete, Greece 2007-2009. The analysis included 1091 women with singleton pregnancies, providing complete data on sleeping habits at the third trimester of gestation and birth outcomes. Fetal growth restriction was based on a customized model, and multivariate log-binomial regression models were used to adjust for confounders.Results: Women with severe snoring were at high risk for low birth weight (relative risk = 2.6 [95% confidence interval = 1.2-5.4]), and fetal-growth-restricted neonates (2.0 [1.0-3.9]) after adjusting for maternal age, education, smoking during pregnancy, and prepregnancy body mass index (BMI). Women with sleep deprivation (