Susceptibility to aplastic anemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia
Susceptibility to aplastic anemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia
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DOI：
10.1016/j.humimm.2011.06.013
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发表时间：
2011-10-01
期刊：
影响因子：
2.7
通讯作者：
Murad, Shahnaz
中科院分区：
文献类型：
--
作者：
Dhaliwal, J. S.;Wong, Lily;Murad, Shahnaz
据报道，亚洲再生障碍性贫血的发病率高于其他地区。我们研究了遗传相似的卡达赞族和杜孙族再生障碍性贫血患者的人类白细胞抗原（HLA） DRB1等位基因的频率，并与遗传匹配的社区和医院对照进行了比较。HLA-DRB1*15在患者中显著高于对照组（p = 0.005），证实了日本和高加索研究的类似结果。进一步检测发现，患者HLA-DRB1*1501的频率明显高于对照组（p = 0.0004），但HLA-DRB1*1502的频率无显著差异。Kadazan和Dusun人群中HLA-DRB1*15的高频率加上与再生障碍性贫血相关的各种环境因素可能是沙巴州Kadazan和Dusun再生障碍性贫血发病率升高的原因。(C) 2011年美国组织相容性和免疫遗传学学会。Elsevier Inc.出版。版权所有。
The incidence of aplastic anemia is reported to be higher in Asia than elsewhere. We studied the frequency of human leukocyte antigen (HLA) DRB1 alleles in aplastic anemia patients from 2 genetically similar aboriginal groups, the Kadazan and the Dusun, and compared them with genetically matched community and hospital controls. HLA-DRB1*15 was significantly higher in the patients compared with controls (p = 0.005), confirming similar findings in Japanese and Caucasian studies. Further testing indicated a significantly higher frequency of HLA-DRB1*1501 in patients compared with controls (p = 0.0004) but no significant difference in the frequency of HLA-DRB1*1502. The high frequency of HLA-DRB1*15 in the Kadazan and Dusun population combined with the wide variety of environmental factors associated with aplastic anemia could be the reason for the elevated incidence of aplastic anemia in the Kadazan and Dusun in Sabah. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.