Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein
Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein
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DOI：
10.1016/j.foodchem.2012.03.043
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发表时间：
2012-10-01
期刊：
影响因子：
8.8
通讯作者：
Chiba, Hitoshi
中科院分区：
文献类型：
--
作者：
Hirata, Hiroshi;Takazumi, Koji;Chiba, Hitoshi
高密度脂蛋白（HDL）胆固醇水平与动脉粥样硬化的低风险相关。胆固醇酯转移蛋白（CETP）催化胆固醇在脂蛋白之间的转移，其抑制导致HDL-胆固醇的增加，并有望成为下一个抗动脉粥样硬化的靶点。本研究揭示，黄腐酚，异戊二烯化的查耳酮，显示出最高的抑制CETP从筛选天然产物在各种植物。我们研究了一些查尔酮和黄烷酮的抑制活性。与黄腐酚相比，柚皮素查耳酮表现出较弱的CETP抑制作用。此外，异黄腐酚和柚皮素显着降低抑制活性。这些结果表明，异戊烯基和查尔酮结构的黄腐酚的CETP抑制活性负责。(C)2012爱思唯尔有限公司保留所有权利。
High density lipoprotein (HDL)-cholesterol levels are correlated with a low risk of atherosclerosis. The inhibition of cholesteryl ester transfer protein (CETP), which catalyses cholesterol transfer between lipoproteins, leads to an increase in HDL-cholesterol and is expected to be the next anti-atherogenic target. This study revealed that xanthohumol, a prenylated chalcone, showed the highest inhibition against CETP from screening of natural products in various plants. We investigated the inhibitory activity of some chalcones and flavanones. Naringenin chalcone showed weak CETP inhibition compared with xanthohumol. In addition, isoxanthohumol and naringenin drastically decreased the inhibitory activity. These results suggest that the prenyl group and chalcone structure of xanthohumol were responsible for the CETP inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.