Decreased Levels of Histidine-Rich Glycoprotein and Increased Levels of High-Mobility Group Box 1 are Risk Factors for Refractory Kawasaki Disease
Decreased Levels of Histidine-Rich Glycoprotein and Increased Levels of High-Mobility Group Box 1 are Risk Factors for Refractory Kawasaki Disease
复制标题
富含组氨酸的糖蛋白水平降低和高迁移率族盒 1 水平升高是难治性川崎病的危险因素
DOI：
10.1093/mr/roac040
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发表时间：
2022
期刊：
影响因子：
2.2
通讯作者：
Tsukahara H
中科院分区：
文献类型：
--
作者：
Namba T;Yashiro M;Fujii Y;Tsuge M;Liu K;Nishibori M;Tsukahara H
目的富含组氨酸的糖蛋白 (HRG) 和高迁移率族蛋白 1 (HMGB1) 调节中性粒细胞和血管内皮的激活。本研究的目的是量化川崎病 (KD) 患者的 HRG 和 HMGB1 水平，并评估它们在 KD 临床管理中的应用。方法本研究是前瞻性进行的。患者被分为两组，并根据 KD 症状在发病第 10 天是否有所改善进行分析。在所有病例的首次治疗前均测量 HRG、HMGB1 和其他实验室变量，在大多数情况下，在治疗后测量 HRG、HMGB1 和其他实验室变量以评估趋势。 结果在这项前瞻性研究中，我们招募了 60 名川崎病患者和 48 名健康对照者。 KD组HRG水平显着低于健康对照组； HMGB1水平没有表现出明显差异。在 KD 组中，HRG 水平与白细胞和中性粒细胞计数呈负相关。在低反应组和有效组中，从治疗前到治疗后，HRG和HMGB1水平分别呈下降趋势。结论HRG和HMGB1与KD的发病有关；HRG和HMGB1与KD的发病有关。低 HRG 和高 HMGB1 水平会导致对 KD 治疗的抵抗。
ObjectivesHistidine-rich glycoprotein (HRG) and high-mobility group box 1 (HMGB1) regulate the activation of neutrophils and vascular endothelium. The aim of this study was to quantify HRG and HMGB1 levels in patients with Kawasaki disease (KD) and evaluate their use in the clinical management of KD.MethodsThis study was prospectively performed. Patients were divided into two groups and analysed depending on whether KD symptoms improved by Day 10 of illness. HRG, HMGB1, and other laboratory variables were measured before the first treatment in all cases and, in most cases, afterwards for assessing trends.ResultsIn this prospective study, we enrolled 60 patients with KD and 48 healthy controls. The HRG level in the KD group was significantly lower than that in the healthy control group; HMGB1 levels showed no obvious differences. In the KD group, HRG levels were negatively correlated with white blood cell and neutrophil counts. In the poor responders and responders groups, a tendency for a decrease in HRG and HMGB1 levels, respectively, was observed from pretreatment to post-treatment.ConclusionsHRG and HMGB1 are related to the pathogenesis of KD; low HRG and high HMGB1 levels cause resistance against KD treatment.