Prevalence of Genital Human Papillomavirus Among Females in the United States, the National Health and Nutrition Examination Survey, 2003-2006
Prevalence of Genital Human Papillomavirus Among Females in the United States, the National Health and Nutrition Examination Survey, 2003-2006
复制标题
DOI：
10.1093/infdis/jir341
复制
发表时间：
2011-08-15
影响因子：
6.4
通讯作者：
Markowitz, Lauri E.
中科院分区：
文献类型：
--
作者：
Hariri, Susan;Unger, Elizabeth R.;Markowitz, Lauri E.
背景。生殖器人乳头瘤病毒 (HPV) 包括超过 40 种性传播病毒。大多数 HPV 感染不会进展为疾病，但某些类型的 HPV 感染可导致宫颈癌和其他肛门生殖器癌和口咽癌，其他类型的 HPV 与肛门生殖器疣有关。 HPV 疫苗可预防 HPV 16 和 18 型（占宫颈癌病例的 70%）以及 HPV 6 和 11 型（占肛门生殖器疣病例的 90%）感染。使用连续国家健康和营养检查调查（2003-2006）中 4150 名 14-59 岁女性的数据和自行收集的宫颈阴道样本，我们估计了特定型 HPV DNA 的流行率，并检查了社会人口学和性别决定因素。结果。 14-59 岁女性中 HPV 的总体患病率为 42.5%，并且因年龄、种族或民族以及性伴侣数量的不同而存在显着差异。个体类型患病率低于 7%，范围从 < 0.5% 到 6.5%。最常见的类型是非致癌 HPV 62（在 6.5% 的受试者中发现），其次是 HPV 53 和 HPV 16 (4.7%)，这两种类型都是致癌类型。最常见的物种是非致癌α 3。结论。 HPV 感染在美国女性中很常见，20-24 岁的年轻女性感染负担最高。监测 HPV 类型分布趋势将有助于我们了解 HPV 疫苗的早期影响。
Background. Genital human papillomaviruses (HPV) include >40 sexually transmitted viruses. Most HPV infections do not progress to disease, but infection with certain types of HPV can cause cervical and other anogenital and oropharyngeal cancer, and other types of HPV are associated with anogenital warts. HPV vaccines prevent infection with HPV 16 and 18, which account for 70% of cases of cervical cancer, and HPV 6 and 11, which cause 90% of the cases of anogenital warts.Methods. Using data and self-collected cervicovaginal specimens from 4150 females, 14-59 years of age, from consecutive National Health and Nutrition Examination Surveys (2003-2006), we estimated the prevalence of type-specific HPV DNA and examined sociodemographic and sexual determinants.Results. The overall prevalence of HPV was 42.5% in females 14-59 years of age and varied significantly by age, race or ethnicity, and number of sex partners. Individual type prevalence was less than 7%, ranging from < 0.5% through 6.5%. The most common type was nononcogenic HPV 62 (found in 6.5% of subjects), followed by HPV 53 and HPV 16 (4.7%), both of which are oncogenic types. The most prevalent species was nononcogenic alpha 3.Conclusions. HPV infection is common among US females, with the highest burden of infection found in young females 20-24 years of age. Monitoring trends in HPV type distribution will contribute to our understanding of the early impact of HPV vaccines.