Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC
Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC
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DOI：
10.1016/j.tetlet.2005.07.083
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发表时间：
2005-09-12
影响因子：
1.8
通讯作者：
Eguchi, T
中科院分区：
文献类型：
--
作者：
Minami, A;Kakinuma, K;Eguchi, T
探索了利用糖基转移酶VinC在一锅反应中将天然糖苷转化为非天然糖苷的新方法。这种糖醛酸开关由两个反应组成，其中NDP-vicenisamine由天然糖苷vicenistatin原位生成，NDP通过逆反应转移到目标附加糖醛酸，通过正向反应形成非天然vicenisaminides。(c) 2005 Elsevier Ltd版权所有。
New aglycon switch approach using glycosyltransferase VinC was explored to create unnatural glycosides from natural glycoside in one-pot reaction. This aglycon switch comprises from two reactions, where NDP-vicenisamine generated in situ from natural glycoside vicenistatin and NDP by the reverse reaction is transferred to the targeted additional aglycons to form unnatural vicenisaminides by the forward reaction. (c) 2005 Elsevier Ltd. All rights reserved.