Platelet Activation Markers Are Associated with Crohn's Disease Activity in Patients with Low C-Reactive Protein
Platelet Activation Markers Are Associated with Crohn's Disease Activity in Patients with Low C-Reactive Protein
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DOI：
10.1007/s10620-015-3745-2
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发表时间：
2015-11-01
影响因子：
3.1
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
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作者：
Takeyama, Hiroshi;Mizushima, Tsunekazu;Mori, Masaki
在评估克罗恩病(CD)活动性时，C反应蛋白(CRP)是一个重要的炎症指标；然而，它并不一定与克罗恩病活动指数(CDAI)有关，特别是在低CRP患者。近年来，由于血小板活化因子在炎症反应中的重要作用而被公认。本研究旨在探讨CDAI与血小板第4因子(PF-4)、β-血栓球蛋白(β-TG)等凝血和纤溶因子的相关性，并对47例CD合并低C反应蛋白(1 mg/dl)患者的9项指标：C反应蛋白、血小板计数、白细胞计数、纤维蛋白原和纤维蛋白原降解产物、纤维蛋白原、凝血酶-抗凝血酶复合体、凝血酶原片段1+2、凝血酶原4和β-甘油三酯进行检测。患者被分成疾病活跃度高或低的两组，CDAI-H(CDAI-H)和CDAI-L(CDAI<；150)。CDAI-H的PF-4和β-TG水平显著高于CDAI-L(P<；0.01)。其他标记物在组间无显著差异。CDAI与PF-4、β-TG呈正相关(P分别为0.0033和0.0024，r分别为0.4202和0.4321)。受试者操作特征曲线分析显示，PF-4和β-TG对CD活动期的诊断具有较高的敏感性(分别为61.9%和81%)和特异性(分别为84.7%和69.2%)。在8种潜在标志物中，PF-4和β-TG与CD和低CRP患者的CDAI相关性最高。PF-4和β-TG水平有望成为评价低C反应蛋白患者CD的新指标。
In assessing Crohn's disease (CD) activity, C-reactive protein (CRP) is an important indicator of inflammation; however, it is not necessarily associated with the Crohn's Disease Activity Index (CDAI), particularly in patients with low CRP. Recently, platelet activation factors have been recognized due to their importance in the inflammatory response. In this study, we examined associations between the CDAI and platelet factor 4 (PF-4), beta-thromboglobulin (beta-TG), and other coagulation and fibrinolysis factors.We aimed to find a new marker for evaluating disease activity in patients with CD and low CRP.Nine markers, including CRP, platelet count, white blood cell count, fibrin and fibrinogen degradation product, fibrinogen, thrombin-antithrombin complex, prothrombin fragments 1 + 2, PF-4, and beta-TG were evaluated in 47 patients with CD and low CRP (< 1.0 mg/dl). Patients were assigned to high or low disease activity groups, CDAI-H (CDAI a parts per thousand yen 150) and CDAI-L (CDAI < 150), respectively.CDAI-H exhibited significantly higher PF-4 and beta-TG levels than CDAI-L (P < 0.01). Other markers were not significantly different between groups. CDAI was positively correlated with the levels of PF-4 and beta-TG (P = 0.0033 and 0.0024; r = 0.4202 and 0.4321, respectively). Receiver operating characteristic curve analyses of PF-4 and beta-TG showed high sensitivity (61.9 and 81 %, respectively) and specificity (84.7 and 69.2 %, respectively) for diagnosing active CD.Among eight potential markers, PF-4 and beta-TG were the most highly correlated with CDAI in patients with CD and low CRP. PF-4 and beta-TG levels showed promise as new markers for assessing CD in patients with low CRP.