Emotional attribution in high-functioning individuals with autistic spectrum disorder: A functional imaging study
Emotional attribution in high-functioning individuals with autistic spectrum disorder: A functional imaging study
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DOI：
10.1097/00004583-200404000-00014
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发表时间：
2004-04-01
影响因子：
13.3
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Piggot, J;Kwon, H;Reiss, AL
目的：确定是否专业知识的情感归因于基本面部表情的高功能个体自闭症谱系障碍（ASD）的杏仁核，梭状核和前额叶感兴趣区（ROI）的支持，并与典型的发展中国家的个人。方法：从14名男性ASD患者和10名匹配的青少年对照中获得功能磁共振成像扫描，同时执行情感匹配（EM）（感知），情感标签（EL）（语言）和控制任务。测量每个ROI的准确度、响应时间和平均激活。结果：在准确性、响应时间或ROI方面没有显著差异。执行EL任务的组之间的激活。ASD组与对照组一样准确地执行EM任务，但具有显着更长的反应时间和更低的平均梭形激活。结论：在高功能ASD组中，从基本面部表情中对情绪归因的专业知识是任务依赖的。假设高功能ASD组将是不太专业，并会减少梭状回激活支持知觉任务，但不是语言任务。减少梭状激活的知觉任务没有解释减少专业知识，因此得出结论，减少梭状激活与ASD的诊断。
Objective: To determine whether expertise in the attribution of emotion from basic facial expressions in high-functioning individuals with autistic spectrum disorder (ASD) is supported by the amygdala, fusiform, and prefrontal regions of interest (ROI) and is comparable to that of typically developing individuals. Method: Functional magnetic resonance imaging scans were acquired from 14 males with ASD and 10 matched adolescent controls while performing emotion match (EM) (perceptual), emotion label (EL) (linguistic), and control tasks. Accuracy, response time, and average activation were measured for each ROI. Results: There was no significant difference in accuracy, response time, or ROI. activation between groups performing the EL task. The ASD group was as accurate as the control group performing the EM task but had a significantly longer response time and lower average fusiform activation. Conclusions: Expertise in the attribution of emotion from basic facial expressions was task-dependent in the high-functioning ASD group. The hypothesis that the high-functioning ASD group would be less expert and would have reduced fusiform activation was supported in the perceptual task but not the linguistic task. The reduced fusiform activation in the perceptual task was not explained by reduced expertise; it is therefore concluded that reduced fusiform activation is associated with the diagnosis of ASD.