S100 and cognitive impairment after mild traumatic brain injury
S100 and cognitive impairment after mild traumatic brain injury
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DOI：
10.1080/16501970410015587
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Borg, J
中科院分区：
文献类型：
--
作者：
de Boussard, CN;Lundin, A;Borg, J
目的：探讨S100B和S100A1B蛋白与轻型颅脑损伤(MTBI)后3个月认知功能障碍症状和体征的关系。方法：采用前瞻性队列研究方法，对格拉斯哥昏迷评分为14或15分的MTBI患者进行血清S100A1B和S100B水平检测。采用Rivermead震荡后症状问卷进行症状评定。结果：S100B和S100A1B浓度分别有31%和48%高于临界值。根据计算机化的神经心理测试，8%的患者有认知障碍的迹象，根据扩展测试，30%的患者有认知障碍的迹象。44%的患者在受伤后第一天报告了认知障碍的症状，在3个月时有26%的患者报告了认知障碍的症状。未发现S100B或S100A1B浓度与认知损害症状或体征之间的显著相关性。结论：在MTBI和格拉斯哥昏迷评分为14或15分的患者中，S100血清浓度异常和认知损害症状或体征之间无显著相关性。
Objective: The aim of this study was to explore the relationship between the proteins S100B and S100A1B and symptoms and signs of cognitive impairment for 3 months after mild traumatic brain injury (MTBI).Methods: Serum concentrations of S100A1B and S100B were examined in a prospective cohort study of patients with MTBI and a Glasgow Coma Scale score of 14 or 15. Cognitive performance was assessed by repeated computerized neuropsychological testing and an extended neuropsychological test. Symptoms were assessed using the Rivermead Post-Concussion Symptoms Questionnaire.Results: Concentrations of S100B and S100A1B were above cut-off in 31% and 48% respectively. Eight percent of the patients had signs of cognitive impairment according to the computerized neuropsychological tests and 30% according to the extended test. Symptoms of cognitive impairment were reported by 44% of the patients on the first day post-injury and by 26% at 3 months. No significant associations between S100B or S100A1B concentrations and symptoms or signs of cognitive impairment were found.Conclusion: Abnormal S100 serum concentrations and symptoms or signs of cognitive impairment were not significantly associated in patients with MTBI and a Glasgow Coma Scale score of 14 or 15.