Subregional Mesiotemporal Network Topology Is Altered in Temporal Lobe Epilepsy
Subregional Mesiotemporal Network Topology Is Altered in Temporal Lobe Epilepsy
复制标题
DOI：
10.1093/cercor/bhv166
复制
发表时间：
2016-07-01
期刊：
影响因子：
3.7
通讯作者：
Bernasconi, Andrea
中科院分区：
文献类型：
--
作者：
Bernhardt, Boris C.;Bernasconi, Neda;Bernasconi, Andrea
颞叶癫痫（TLE）是成人中最常见的耐药性癫痫，通常与磁共振成像（MRI）上不同程度的近中颞叶萎缩相关。对区域间连通性的分析揭示了大规模皮质-皮质网络的中断;对近中颞叶的拓扑组织知之甚少，边缘子网络是这种疾病的核心。我们基于134名TLE患者和45名年龄和性别匹配的对照组的海马、内嗅皮层和杏仁核的高分辨率MRI表面形状描述符生成协方差网络。图形理论分析显示患者的路径长度增加和聚类，表明向更规则化的排列转变;在分半评估和2个包裹方案中，结果是可重复的。区域间的相关性和模块参与的分析表明，增加结构内的协方差，但结构之间的减少，特别是关于海马和杏仁核。虽然较高的聚类可能反映了轴突发芽的拓扑后果，但结构间协方差的降低可能是边缘系统电路断开的结果。术前网络参数，特别是同侧海马的分离，预测术后长期癫痫发作自由。
Temporal lobe epilepsy (TLE) is the most frequent drug-resistant epilepsy in adults and commonly associated with variable degrees of mesiotemporal atrophy on magnetic resonance imaging (MRI). Analyses of inter-regional connectivity have unveiled disruptions in large-scale cortico-cortical networks; little is known about the topological organization of the mesiotemporal lobe, the limbic subnetwork central to the disorder. We generated covariance networks based on high-resolution MRI surface-shape descriptors of the hippocampus, entorhinal cortex, and amygdala in 134 TLE patients and 45 age-and sex-matched controls. Graph-theoretical analysis revealed increased path length and clustering in patients, suggesting a shift toward a more regularized arrangement; findings were reproducible after split-half assessment and across 2 parcellation schemes. Analysis of inter-regional correlations and module participation showed increased within-structure covariance, but decreases between structures, particularly with regards to the hippocampus and amygdala. While higher clustering possibly reflects topological consequences of axonal sprouting, decreases in interstructure covariance may be a consequence of disconnection within limbic circuitry. Preoperative network parameters, specifically the segregation of the ipsilateral hippocampus, predicted long-term seizure freedom after surgery.