The Geographic Distribution of Genetic Risk as Compared to Social Risk for Chronic Diseases in the United States.
The Geographic Distribution of Genetic Risk as Compared to Social Risk for Chronic Diseases in the United States.
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美国慢性病遗传风险与社会风险的地理分布比较。
DOI：
10.1080/19485565.2016.1141353
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发表时间：
2016
影响因子：
1.3
通讯作者：
Cullen,MarkR
中科院分区：
文献类型：
--
作者：
Rehkopf,DavidH;Domingue,BenjaminW;Cullen,MarkR
慢性病与地理环境之间存在关联，有证据表明，环境在这种关系中起着关键作用。然而，与此同时，众所周知，美国各地的血统存在着很大的地理差异。由此产生的地理遗传变异--即与慢性疾病相关的单核苷酸多态(SNPs)在空间上的差异程度--可能因此推动地理与疾病之间的部分联系。我们从冠状动脉疾病、糖尿病和缺血性中风的全基因组关联研究荟萃分析中提取风险SNPs，并创建多基因风险评分，从而描述了出生状态对慢性疾病遗传风险的影响。我们将这些多基因得分在出生州之间的变异量与父母教育、自身教育、收入和财富的变异性进行比较。我们的主要发现是，多基因风险分数在美国各州之间的差异很小。与社会和经济因素的分布相比，地理分布的差异非常小，因此不太可能对美国各州的地理疾病差异产生有意义的影响。
There is an association between chronic disease and geography, and there is evidence that the environment plays a critical role in this relationship. Yet at the same time, there is known to be substantial geographic variation by ancestry across the United States. Resulting geographic genetic variation—that is, the extent to which single nucleotide polymorphisms (SNPs) related to chronic disease vary spatially—could thus drive some part of the association between geography and disease. We describe the variation in chronic disease genetic risk by state of birth by taking risk SNPs from genome-wide association study meta-analyses for coronary artery disease, diabetes, and ischemic stroke and creating polygenic risk scores. We compare the amount of variability across state of birth in these polygenic scores to the variability in parental education, own education, earnings, and wealth. Our primary finding is that the polygenic risk scores are only weakly differentially distributed across U.S. states. The magnitude of the differences in geographic distribution is very small in comparison to the distribution of social and economic factors and thus is not likely sufficient to have a meaningful effect on geographic disease differences by U.S. state.