Megastigmane and phenolic components from Laurus nobilis L. leaves and their inhibitory effects on nitric oxide production
Megastigmane and phenolic components from Laurus nobilis L. leaves and their inhibitory effects on nitric oxide production
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DOI：
10.1021/jf048782t
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发表时间：
2004-12-15
影响因子：
6.1
通讯作者：
Iorizzi, M
中科院分区：
文献类型：
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作者：
De Marino, S;Borbone, N;Iorizzi, M
月桂叶子被广泛用于烹饪和民间医药。从白木香的甲醇提取物中分离得到5个新的巨替加曼苷（2-4，7，9），命名为月桂苷A-E和一个新的酚苷12。黄花属叶，沿着具有10种已知组分：巨替格曼（5），巨替格曼葡糖苷（1，6，8，10和11），芳香化合物（13和14）。和类黄酮（15和16）。通过一维和二维核磁共振实验（H-1和C-13 NMR，DEPT.相关光谱、异质多量子相关、异质多键相关和核Overhauser增强光谱）和化学衍生化。检测了分离的化合物对脂多糖激活的小鼠巨噬细胞中一氧化氮产生的影响。
Laurus nobilis L. leaves are widely used in cooking and in folk medicine. Five new megastigmane glucosides (2-4, 7, and 9) named laurosides A-E and a new phenolic glucoside 12 were isolated from the methanolic extract of L. nobilis L. leaves, along with 10 known components: megastigmane (5), megastigmane glucosides (1, 6, 8, 10, and 11), aromatic compounds (13 and 14). and flavonoids (15 and 16). The structures and relative stereochemistry have been elucidated by one- and two-dimensional nuclear magnetic resonance experiments (H-1 and C-13 NMR, DEPT. correlation spectroscopy, heteronuclear multiple quantum correlation, heteronuclear multiple bond correlation, and nuclear Overhauser enhancement spectroscopy) and by chemical derivatization. The effect of isolated compounds on nitric oxide production in lipopolysaccharide-activated murine macrophages were examined.