A MOUSE Y-CHROMOSOME GENE ENCODED BY A REGION ESSENTIAL FOR SPERMATOGENESIS AND EXPRESSION OF MALE-SPECIFIC MINOR HISTOCOMPATIBILITY ANTIGENS
A MOUSE Y-CHROMOSOME GENE ENCODED BY A REGION ESSENTIAL FOR SPERMATOGENESIS AND EXPRESSION OF MALE-SPECIFIC MINOR HISTOCOMPATIBILITY ANTIGENS
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DOI：
10.1093/hmg/3.6.873
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发表时间：
1994-06-01
影响因子：
3.5
通讯作者：
BISHOP, CE
中科院分区：
文献类型：
--
作者：
AGULNIK, AI;MITCHELL, MJ;BISHOP, CE
一个新的小鼠Y染色体基因，Smcy，已被分离出的区域编码Spy，精子发生基因和Hya和SDMA，基因，分别控制的表达，男性特异性次要组织相容性抗原H-Y，测定特定的T细胞分析和血清学检测的男性抗原SDMA。Smcy在小鼠、人甚至有袋动物的Y染色体上都很保守。它在测试的所有成年雄性组织中表达，并且也可以在小鼠发育期间早在两个细胞中检测到。此外，其人Y同源物SMCY在多种组织中表达，并定位于与人H-Y抗原控制基因座HY相同的Yq缺失区间。
A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermatogenesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically detected male antigen SDMA. Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY.