The Potential Role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance-Its Effect on Paraproteinemia and the Urinary N-Telopeptide of Type I Collagen Bone Turnover Marker
The Potential Role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance-Its Effect on Paraproteinemia and the Urinary N-Telopeptide of Type I Collagen Bone Turnover Marker
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DOI：
10.1158/1078-0432.ccr-08-2217
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发表时间：
2009-09-15
影响因子：
11.5
通讯作者：
Ramakrishna, Rajeev
中科院分区：
文献类型：
--
作者：
Golombick, Terry;Diamond, Terrence H.;Ramakrishna, Rajeev
目的：探讨姜黄素对MGUS患者血浆细胞和破骨细胞的影响。实验设计：26例MGUS患者口服姜黄素4g/d。在开始治疗后的特定就诊时采集血样和尿样。所有患者均于每次就诊时检测全血计数、B_2微球蛋白、血清副蛋白和免疫球蛋白电泳值。仅在基线时测定血钙、25羟基维生素D3和骨特异性碱性磷酸酶。结果：我们的结果显示，口服姜黄素能够降低部分MGUS患者(即副蛋白水平为>；20g/L)患者的副蛋白负荷。其中50%(5/10)的患者在接受姜黄素治疗时，他们的副蛋白水平降低了12%到30%。此外，服用姜黄素的患者中有27%的患者尿I型胶原N端肽减少了25%。结论：由于MGUS可能进展为多发性骨髓瘤，姜黄素作为MGUS患者的治疗干预措施的潜在作用值得进一步研究。(临床癌症研究报告2009；15(18)：5917-22)
Purpose: To determine the effect of curcumin on plasma cells and osteoclasts in patients with MGUS.Experimental Design: Twenty-six patients with MGUS were recruited into the study and administered 4 grams/day oral curcumin. Blood and urine samples were collected at specified visits after initiating therapy. Full blood count, B2 microglobulin, serum paraprotein, and immunoglobulin electrophoresis (IEPG and EPG) were determined for all patients at each visit. Serum calcium, 25 hydroxyvitamin D3, and bone-specific alkaline phosphatase were determined at baseline only. Urine, as a morning second-void sample, was collected at each visit for urinary N-telopeptide of type I collagen.Results: Our results show that oral curcumin is able to decrease paraprotein load in a select group (i.e., those having a paraprotein level of > 20 g/L) of patients with MGUS. Fifty percent (5 of 10) of these patients had a 12% to 30% reduction in their paraprotein levels, while on curcumin therapy. In addition, 27% of patients on curcumin had a > 25% decrease in urinary N-telopeptide of type I collagen.Conclusion: Due to the possible progression of MGUS to multiple myeloma, the potential role of curcumin as a therapeutic intervention for MGUS patients warrants further investigation. (Clin Cancer Res 2009;15(18):5917-22)