The force-load-velocity relation and the viscous-like force in the frog skeletal muscle.
The force-load-velocity relation and the viscous-like force in the frog skeletal muscle.
复制标题
青蛙骨骼肌中的力-载荷-速度关系和类粘性力。
DOI：
10.2170/jjphysiol.22.103
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
K. Fujii
中科院分区：
文献类型：
--
作者：
H. Mashima;K. Akazawa;H. Kushima;K. Fujii
本文测定了蛙半腱肌小束在不同收缩力作用下的负荷-速度关系。1)纤维束的拉伸曲线与单纤维的拉伸曲线基本一致。2)在标准长度Lo下测得的缩短肌在任何收缩力下的负荷-速度曲线均符合HILL双曲线方程，在10·cm-1时的动力学常数为a/Po = 0.25和B/Lo = 0.9/sec。在给定速度下，类粘性力Fv随收缩力F的增加而线性增加。这些结果在0.8和1.2 Lo之间的长度区域内有效。3)在任何收缩力下，延长肌肉的负荷-速度曲线也是双曲线，并且除非速度超过1.0 Lo/秒，否则Fv也与F成正比。动力学常数为a ′/Po = 0.4和b ′/Lo = 0.85 /sec，即，a ′/Po比a/Po大1.6倍。4)将HILL的力-速度方程推广为力（F）载荷（P）-速度（v）方程（P+A）（v+B）= B（F + A），A = aF/Po;或力-Fv-速度方程Fv =（F/Po）（Po+a）v/（v+B）。5)在相同的收缩力和收缩速度下，延长时的Fv值是缩短时的1.4倍。6)这些力-负荷-速度方程不仅在收缩力稳定时有效，而且在收缩力变化时也适用。7)FV，或力依赖性粘度的意义，相对于滑动细丝理论进行了讨论。
The load-velocity relations were determined at various contractile forces in the small bundle dissected from frog semitendinosus muscle. 1) The tension-extension curve of the bundle was nearly the same as that of single fibers. 2) The load-velocity curves of shortening muscle obtained at the standard length Lo fit HILL'S hyperbolic equation at any contractile force in the partially activated muscle, and the dynamic constants were a/Po = 0.25 and b/Lo = 0.9/sec at 10•Ž. The viscous-like force Fv at a given velocity increased linearly with increasing contractile force F. These results were valid in the length region between 0.8 and 1.2 Lo. 3) The load-velocity curves of lengthening muscle were also hyperbolic at any contractile force and Fv was also proportional to F, unless the velocity exceeded 1.0 Lo/sec. The dynamic constants were a'/Po = 0.4 and b'/Lo = 0.85 /sec, i.e., a'/Po was 1.6 times larger than a/Po. 4) HILL's force-velocity equation was generalized to the force (F)load(P)-velocity(v) equation (P+A)(v+b) = b(F + A), A = aF/Po; or the force-Fv-velocity equation Fv = (F/Po)(Po+a)v/(v+b). 5) The value of Fv on lengthening was 1.4 times larger than that on shortening under the same contractile force and velocity. 6) These force-load-velocity equations were valid not only during steady contractile force but also for any instance during the change in contractile force. 7) The significance of Fv, or force-dependent viscosity, is discussed with respect to the sliding filament theory.