Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin A on S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides
Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin A on S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides
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DOI：
10.1128/iai.66.8.3971-3973.1998
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发表时间：
1998-08
影响因子：
3.1
通讯作者：
H. Schroten;Christoph Stapper;R. Plogmann;H. Köhler;J. Hacker;F. Hanisch
中科院分区：
文献类型：
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作者：
H. Schroten;Christoph Stapper;R. Plogmann;H. Köhler;J. Hacker;F. Hanisch
摘要S菌毛大肠埃希菌可引起新生儿败血症和脑膜炎，并能识别糖类序列唾液酸-(α2-3)-半乳糖苷。我们发现克隆的S菌毛大肠杆菌与人上皮细胞的黏附可被分泌型免疫球蛋白A上的唾液寡糖(S-Ig A)独立地抑制。这表明S-免疫球蛋白A(Fc)具有抗感染作用，尤其是在早期母乳中。
ABSTRACT S-fimbriated Escherichia coli strains cause sepsis and meningitis in newborns and are known to recognize the carbohydrate sequence sialyl-(α2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sialyloligosaccharides on secretory immunoglobulin A (s-IgA). This indicates an anti-infective function of s-IgA (Fc), particularly in early human milk.