Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats
Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats
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DOI：
10.3109/07357907.2011.626476
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Rossi Fanelli, Filippo
中科院分区：
文献类型：
--
作者：
Laviano, Alessandro;Molfino, Alessio;Rossi Fanelli, Filippo
细胞因子表达增加有助于癌症恶病质综合征的发病机制。肉毒碱可以减少慢性疾病的炎症。我们测试了L-丙酰肉碱（PC组）或生理盐水（C组）对MCA肉瘤荷瘤大鼠的食物摄入量（FI）、身体成分和炎症状态的影响。在肿瘤出现时，将大鼠随机分配至每日腹膜内注射L-丙酰肉碱（250 mg/kgBW/d; n = 8）或生理盐水（等体积; n = 8）。FI和无脂体重减少仅在PC大鼠中得到改善（p
Increased cytokine expression contributes to the pathogenesis of cancer anorexia-cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p