Cancer stem cells and epithelial ovarian cancer.
Cancer stem cells and epithelial ovarian cancer.
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DOI：
10.1155/2010/105269
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发表时间：
2010
影响因子：
--
通讯作者：
Dafou D
中科院分区：
文献类型：
--
作者：
Dyall S;Gayther SA;Dafou D
癌症干细胞假说作为一种致癌模型越来越被广泛接受。肿瘤在分子和细胞水平上都是异质性的，包含具有高度致瘤性“干细胞”特性的小细胞群体。癌症干细胞（CSC）或肿瘤起始细胞具有自我更新的能力，产生异种移植物，使人想起它们所来源的原发性肿瘤，并且具有化学抗性。肿瘤内CSC群体的特征可以驱动其生长，从而提供针对这些细胞的新型靶向治疗方法，完全根除癌症。已经有几份报告描述了几种癌症中推定的癌症干细胞群的分离;然而，尚未确定确定一组标志物，其最终表征“干细胞样”癌细胞。本文重点介绍了目前已在该领域使用的实验方法，并讨论了它们的局限性，特别强调上皮性卵巢癌中CSC群体的识别和表征。
The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells specifically, eradicating the cancer completely. There have been several reports describing the isolation of putative cancer stem cell populations in several cancers; however, no defined set of markers has been identified that conclusively characterises “stem-like” cancer cells. This paper highlights the current experimental approaches that have been used in the field and discusses their limitations, with specific emphasis on the identification and characterisation of the CSC population in epithelial ovarian cancer.