Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-based lymph node negative breast cancer cohort
Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-based lymph node negative breast cancer cohort
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DOI：
10.1002/ijc.25091
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发表时间：
2010-08-15
影响因子：
6.4
通讯作者：
Fjallskog, M. -L.
中科院分区：
文献类型：
--
作者：
Nimeus-Malmstrom, E.;Koliadi, A.;Fjallskog, M. -L.
很大一部分淋巴结阴性乳腺癌患者不能从化疗中获益。增殖标记物已被证明可以识别复发风险高的患者。Ki67蛋白最近被纳入St Gallen指南。作者调查了细胞周期蛋白B1在淋巴结阴性乳腺癌中的预后重要性，并纳入了一项可重复性研究。在一项基于人群的病例对照研究中，190名死于乳腺癌的妇女被定义为病例，190名在相应病例死亡时存活的妇女被定义为对照。入选标准为肿瘤大小
A large proportion of women with lymph node negative breast cancer do not benefit from chemotherapy. Proliferation markers have been shown to recognize patients at high risk for recurrence. The Ki67 protein has recently been included in the St Gallen guidelines. The authors investigated the prognostic importance of cyclin B1 in node negative breast cancer and included a study of reproducibility. In a population-based case-control study, 190 women who died from breast cancer were defined as cases and 190 women alive at the time for the corresponding case's death were defined as controls. Inclusion criteria were tumor size