A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease.
A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease.
复制标题
川崎病静脉免疫球蛋白抵抗六种预测模型的疗效比较
DOI：
10.1186/s13052-018-0475-z
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发表时间：
2018-03-09
影响因子：
3.6
通讯作者：
Lv H
中科院分区：
文献类型：
--
作者：
Qian W;Tang Y;Yan W;Sun L;Lv H
研究背景川崎病（Kawasaki disease，KD）是小儿最常见的血管炎。已经建立了几种模型来预测静脉注射免疫球蛋白（IVIG）的耐药性。本研究的目的是评估预测模型的有效性，使用的医疗数据的KD patient.MethodsWe收集的病历在苏州大学儿童医院心内科住院的诊断为KD从2015年1月至2016年12月。IVIG抵抗定义为IVIG输注结束后≥36 h反复发热或持续发热。C反应蛋白、谷草转氨酶、中性粒细胞比例（N%）、总胆红素水平升高，白蛋白水平降低。我们的预测模型的敏感性为0.72，特异性为0.75。小林、江上、川村、佐野和福尔摩沙的敏感度分别为0.72、0.44、0.48、0.20和0.68。这些模型的特异性分别为0.62，0.82，0.66，0.91，和0.48.ConclusionsOur预测模型在这方面有很强的预测价值，其次是小林模型，而所有其他预测模型的性能不如我们。
BackgroundKawasaki disease (KD) is the most common pediatric vasculitis. Several models have been established to predict intravenous immunoglobulin (IVIG) resistance. The present study was aimed to evaluate the efficacy of prediction models using the medical data of KD patients.MethodsWe collected the medical records of patients hospitalized in the Department of Cardiology in Children’s Hospital of Soochow University with a diagnosis of KD from Jan 2015 to Dec 2016. IVIG resistance was defined as recrudescent or persistent fever ≥36 h after the end of their IVIG infusion.ResultsPatients with IVIG resistance tended to be younger, have higher occurrence of rash and changes of extremities. They had higher levels of c-reactive protein, aspartate aminotransferase, neutrophils proportion (N%), total bilirubin and lower level of albumin. Our prediction model had a sensitivity of 0.72 and a specificity of 0.75. Sensitivity of Kobayashi, Egami, Kawamura, Sano and Formosa were 0.72, 0.44, 0.48, 0.20, and 0.68, respectively. Specificity of these models were 0.62, 0.82, 0.66, 0.91, and 0.48, respectively.ConclusionsOur prediction model had a powerful predictive value in this area, followed by Kobayashi model while all the other prediction models had less excellent performances than ours.
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影响因子：
37.8
作者：
Kobayashi, Tohru;Inoue, Yoshinari;Morikawa, Akihiro
通讯作者：
Morikawa, Akihiro
DOI：
10.1084/jem.20151853
发表时间：
2016-09-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Stock AT;Hansen JA;Sleeman MA;McKenzie BS;Wicks IP
通讯作者：
Wicks IP
影响因子：
3.7
作者：
Takeshita S;Kanai T;Kawamura Y;Yoshida Y;Nonoyama S
通讯作者：
Nonoyama S
影响因子：
5.1
作者：
Egami, Kimiyasu;Muta, Hiromi;Matsuishi, Toyojiro
通讯作者：
Matsuishi, Toyojiro
影响因子：
8
作者：
Saundankar, Jelena;Yim, Deane;Burgner, David
通讯作者：
Burgner, David