Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology
Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology
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DOI：
10.1038/nri2629
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发表时间：
2009-10-01
影响因子：
100.3
通讯作者：
Pulendran, Bali
中科院分区：
文献类型：
--
作者：
Pulendran, Bali
尽管它们取得了巨大的成功，但我们对有效的疫苗如何刺激保护性免疫反应知之甚少。最近的两项进展有望产生这样的理解：对先天免疫系统在感知微生物和调节免疫反应方面的关键作用的认识，以及系统生物学的进展。在这里，我回顾了这些发展是如何深入了解黄热病疫苗的作用机制，黄热病疫苗是有史以来最成功的疫苗之一，以及对疫苗学的更广泛影响。
Despite their great success, we understand little about how effective vaccines stimulate protective immune responses. Two recent developments promise to yield such understanding: the appreciation of the crucial role of the innate immune system in sensing microorganisms and tuning immune responses, and advances in systems biology. Here I review how these developments are yielding insights into the mechanism of action of the yellow fever vaccine, one of the most successful vaccines ever developed, and the broader implications for vaccinology.