Rationalization of anomalous nonlinear effects in the alkylation of substituted benzaldehydes
Rationalization of anomalous nonlinear effects in the alkylation of substituted benzaldehydes
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DOI：
10.1021/ja027406r
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发表时间：
2002-11-20
影响因子：
15
通讯作者：
Blackmond, DG
中科院分区：
文献类型：
--
作者：
Buono, F;Walsh, PJ;Blackmond, DG
通过对Noyori模型的简单扩展，合理地解释了取代苯甲醛与二乙基锌在氨基醇催化剂上的烷基化反应中的反常非线性效应，以允许非热力学控制的催化剂在单体和二聚物种之间的分配。这项工作强调了这样一个事实，即这种体系中的催化剂组成可能会受到底物性质的影响。
Anomalous nonlinear effects in the alkylation of substituted benzaldehydes with diethylzinc using aminoalcohol catalysts are rationalized in terms of a simple extension of the Noyori model to allow for nonthermodynamically controlled partitioning of the catalyst between monomeric and dimeric species. This work highlights the fact that catalyst composition in such systems may be influenced by substrate properties.