The Dynamics of Apoptotic Cell Clearance.
The Dynamics of Apoptotic Cell Clearance.
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DOI：
10.1016/j.devcel.2016.06.029
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发表时间：
2016-07-25
影响因子：
11.8
通讯作者：
Ravichandran KS
中科院分区：
文献类型：
--
作者：
Elliott MR;Ravichandran KS
吞噬细胞对组织中垂死细胞的清除是由复杂的信号网络协调的一系列高度协调的细胞间事件。来自遗传、生物化学和活体成像方法的最新数据极大地增强了我们对细胞清除动力学以及该过程如何在细胞和组织水平上协调的理解。我们讨论了如何整合调控凋亡细胞清除的网络，以实现组织内快速，高效和高容量的清除系统。
The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.