Learning from Peptides To Access Functional Precision Polymer Sequences
Learning from Peptides To Access Functional Precision Polymer Sequences
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DOI：
10.1002/anie.201902217
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发表时间：
2019-07-01
影响因子：
16.6
通讯作者：
Boerner, Hans G.
中科院分区：
文献类型：
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作者：
Maron, Eva;Swisher, Jordan H.;Boerner, Hans G.
合成了单分散低聚N-取代丙烯酰胺和低聚2-取代-α-羟基酸的功能性精密聚合物。离散序列源自具有充分研究的性质的肽的侧链功能性序列的直接翻译。先前选择的肽溶解光敏剂间-四（羟基苯基）二氢卟酚。所得的肽模拟物制剂添加剂保持母体肽的药物溶解和释放特性。在某些情况下，可以获得优异的上级性能，有效负载提高高达40%，初始药物释放速度加快27倍。
Functional precision polymers based on monodisperse oligo(N-substituted acrylamide)s and oligo(2-substituted-alpha-hydroxy acid)s have been synthesized. The discrete sequences originate from a direct translation of side-chain functionality sequences of a peptide with well-studied properties. The peptide was previously selected to solubilize the photosensitizer meta-tetra(hydroxyphenyl)chlorin. The resulting peptidomimetic formulation additives preserve the drug solubilization and release characteristics of the parent peptide. In some cases, superior properties are obtained, reaching up to 40 % higher payloads and 27-times faster initial drug release.