Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines
Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines
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DOI：
10.1086/338569
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发表时间：
2002-02-01
影响因子：
6.4
通讯作者：
Peeling, RW
中科院分区：
文献类型：
--
作者：
Smith, JS;Muñoz, N;Peeling, RW
在人乳头瘤病毒(HPV)感染的妇女中，研究了沙眼衣原体感染与浸润性宫颈癌(ICC)的关系。总共包括来自巴西圣保罗和菲律宾马尼拉的499名发生ICC的女性患者和539名对照患者。用微量免疫荧光法检测沙眼衣原体抗体。采用聚合酶链式反应方法检测宫颈标本中HPVDNA的存在。沙眼衣原体血清阳性与性行为有关，但与HPV感染无关。沙眼衣原体增加了HPV阳性妇女患宫颈鳞癌的风险(优势比，2.1；95%可信区间，1.1-4.0)。这两个国家的结果是相似的。有迹象表明，随着沙眼衣原体抗体效价的增加，患鳞癌的风险也会增加。这项大型研究考察了沙眼衣原体和宫颈癌，并考虑了HPV感染的核心作用。沙眼衣原体感染可能是HPV在宫颈鳞癌发病机制中的一个辅助因素，其作用机制可能与慢性炎症有关。
Chlamydia trachomatis infection was examined as a cause of invasive cervical cancer (ICC) among women with human papillomavirus (HPV) infection. In total, 499 women with incident ICC (ICC patients) and 539 control patients from Sao Paulo, Brazil, and Manila, the Philippines, were included. C. trachomatis antibodies were detected by microimmunofluorescence assay. Presence of HPV DNA in cervical specimens was determined by a polymerase chain reaction-based assay. C. trachomatis seropositivity was associated with sexual behavior but not with HPV infection. C. trachomatis increased the risk of squamous cervical cancer among HPV-positive women (odds ratio, 2.1; 95% confidence interval, 1.1-4.0). Results were similar in both countries. There was a suggestion of increasing squamous cancer risk with increasing C. trachomatis antibody titers. This large study examined C. trachomatis and cervical cancer, taking into account the central role of HPV infection. C. trachomatis infection was found to be a possible cofactor of HPV in the etiology of squamous cervical cancer, and its effect may be mediated by chronic inflammation.