Innate or adaptive immunity? The example of natural killer cells.
Innate or adaptive immunity? The example of natural killer cells.
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DOI：
10.1126/science.1198687
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发表时间：
2011-01-07
期刊：
影响因子：
--
通讯作者：
Ugolini S
中科院分区：
文献类型：
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作者：
Vivier E;Raulet DH;Moretta A;Caligiuri MA;Zitvogel L;Lanier LL;Yokoyama WM;Ugolini S
自然杀伤（NK）细胞最初被定义为具有组成性溶细胞功能的先天免疫效应淋巴细胞。最近，出现了对NK细胞更微妙的看法。NK细胞现在被认为表达活化和抑制受体的库，其被校准以确保自身耐受性，同时允许对攻击如病毒感染和肿瘤发展的功效。此外，NK细胞不会以不变的方式反应，而是适应其环境。最后，最近的研究揭示了NK细胞也可以装载一种形式的抗原特异性免疫记忆。因此，NK细胞发挥复杂的生物学功能，这些功能是先天免疫和适应性免疫的属性，模糊了免疫应答这两个分支之间的功能边界。
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response.