Association of rs1122608 with Coronary Artery Disease and Lipid Profile: A Meta-analysis
Association of rs1122608 with Coronary Artery Disease and Lipid Profile: A Meta-analysis
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rs1122608 与冠状动脉疾病和脂质谱的关联：荟萃分析。
DOI：
10.1016/j.arcmed.2016.07.014
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发表时间：
2016-05-01
影响因子：
7.7
通讯作者：
Xie, Jianhui
中科院分区：
文献类型：
--
作者：
Liu, Shuo;Xiu, Bingqiu;Xie, Jianhui
背景和目的。据报道，在高加索人群中，低密度脂蛋白胆固醇受体（LDLR）位点附近的rs1122608与冠状动脉疾病（CAD）和血脂的风险相关。由于亚洲人群的结果相互矛盾，我们进行了荟萃分析，系统地总结和澄清rs1122608与CAD风险和血脂之间的关系。在PubMed、Embase、Cochrane等数据库中系统检索rs1122608与CAD风险及血脂相关的研究。比值比（ORs）和95%置信区间（95% ci）用于汇总效应大小。本研究共纳入5项病例对照研究。在总体分析中，rs1122608-G等位基因与CAD风险之间存在统计学意义上的关联（OR = 2.09, 95% CI 1.48-2.97），在亚洲亚组（OR = 1.82, 95% CI 1.04-3.18）和高加索亚组（OR = 2.31, 95% CI 1.48-3.60）中也存在统计学意义上的关联。rs1122608-G等位基因与甘油三酯（TG）水平升高相关（OR = 1.25, 95% CI 1.03-1.52），但与总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）或低密度脂蛋白胆固醇水平无关。此外，rs1122608-G等位基因与亚洲男性人群冠心病风险增加相关（OR = 3.37, 95% CI 1.51-9.86），但与亚洲女性人群无关。rs1122608与CAD和TG水平的风险相关。rs1122608-G等位基因在亚洲男性人群中是CAD的重要危险因素，而在亚洲女性人群中则不是。(c) 2016年度Elsevier Inc.出版。
Background and Aims. It has been reported that rs1122608 adjacent to low-density lipoprotein cholesterol receptor (LDLR) locus is associated with the risk of coronary artery disease (CAD) and blood lipid profile in the Caucasian population. Due to the contradictory results in the Asian population, we conducted a meta-analysis to systematically summarize and clarify the association between rs1122608 with CAD risk and lipid profile.Methods. A systematic search regarding studies on the association of rs1122608 with CAD risk and lipid profile was conducted in databases including PubMed, Embase, and Cochrane library. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size.Results. A total of five case-control studies were included in this study. A statistically significant association was identified between rs1122608-G allele and CAD risk in overall analysis (OR = 2.09, 95% CI 1.48-2.97) and in both Asian (OR = 1.82, 95% CI 1.04-3.18) and Caucasian subgroups (OR = 2.31, 95% CI 1.48-3.60). The rs1122608-G allele was associated with increased triglyceride (TG) level (OR = 1.25, 95% CI 1.03-1.52), but not with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), or LDL cholesterol level. Moreover, the rs1122608-G allele is associated with increased CAD risk in the Asian male population (OR = 3.37, 95% CI 1.51-9.86) but not in the Asian female population.Conclusions. The rs1122608 is associated with the risk of CAD and TG level. The rs1122608-G allele was a significant risk factor of CAD in the Asian male population but not in the Asian female population. (C) 2016 IMSS. Published by Elsevier Inc.