Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats
Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats
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DOI：
10.1016/j.neulet.2004.04.066
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发表时间：
2004-07-22
影响因子：
2.5
通讯作者：
Kubo, T
中科院分区：
文献类型：
--
作者：
Fukumori, R;Nishigori, Y;Kubo, T
我们先前证明内侧杏仁核参与大鼠抑制应激诱导的压力反应。本研究采用伊博tenic酸选择性破坏4周龄自发性高血压大鼠（SHR）内侧杏仁核周围神经元。内侧杏仁核的双侧病变减轻了SHR患者高血压的发展。在整个实验期间，SHR损伤和假损伤之间的体重增加没有差异。这些数据提示内侧杏仁核神经元可能参与SHR高血压的发生。2004爱思唯尔爱尔兰有限公司版权所有。
We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilateral lesions of the medial amygdaloid nucleus attenuated the development of hypertension in SHR. Body weight gain was not different between lesioned and sham-lesioned SHR throughout the experimental periods. These data suggest that neurons in the medial amygdaloid nucleus may be involved in the development of hypertension in SHR. (C) 2004 Elsevier Ireland Ltd. All rights reserved.