Metabolic Tumor Volume and Total Lesion Glycolysis in PET/CT Correlate With the Pathological Findings of Colorectal Cancer and Allow Its Accurate Staging
Metabolic Tumor Volume and Total Lesion Glycolysis in PET/CT Correlate With the Pathological Findings of Colorectal Cancer and Allow Its Accurate Staging
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DOI：
10.1097/rlu.0000000000001332
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发表时间：
2016-10-01
影响因子：
10.6
通讯作者：
Kitagawa, Yuko
中科院分区：
文献类型：
--
作者：
Suzuki, Yoshiyuki;Okabayashi, Koji;Kitagawa, Yuko
简介 PET/CT 在癌症诊断中发挥着重要作用。最近，PET/CT 中的新代谢参数，如代谢肿瘤体积 (MTV) 和总病变糖酵解 (TLG) 已被报道为各种癌症的诊断和预后生物标志物。我们评估了这些代谢参数对结直肠癌（CRC）的诊断价值。方法该研究纳入了2012年8月至2014年3月期间接受CRC手术切除的138例患者。使用不同的SUV阈值测量肿瘤的MTV和TLG。利用ROC曲线和分类回归树分析代谢参数的诊断能力。结果MTV和TLG预测T分期的AUC（0.881-0.892）显着高于SUVmax的AUC（0.824）。在M阶段，MTV和TLG的AUC（0.688-0.723）显着高于SUVmax（0.606）。应用分类和回归树的递归分区表明，区分 T、N 和 M 分期的最重要变量的最佳截止值分别为 MTV2.5 = 9.35 和 63.33 mL、TLG50% = 328.1 和 TLG50% = 94.81。 结论 PET/CT 中的代谢肿瘤体积和 TLG 是可靠的诊断生物标志物。利用这些参数，可以对 CRC 进行更准确的术前诊断。
Introduction PET/CT plays an important role in cancer diagnosis. Recently, novel metabolic parameters in PET/CT such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been reported to be diagnostic and prognostic biomarkers of various cancers. We evaluated the diagnostic value of these metabolic parameters in colorectal cancer (CRC).Methods The study included 138 patients who underwent surgical resection of CRCs between August 2012 and March 2014. The MTVs and TLGs of tumors were measured using various SUV thresholds. The diagnostic abilities of the metabolic parameters were analyzed using ROC curves and classification and regression trees.Results The AUCs of the MTVs and TLGs for predicting T stage (0.881-0.892) were significantly higher than the AUC of the SUVmax (0.824). In the M stage, the AUCs of MTVs and TLGs (0.688-0.723) were significantly higher than that of the SUVmax (0.606). Recursive partitioning applying classification and regression trees demonstrated that the optimal cutoff values of the most important variables for discriminating T, N, and M stages are MTV2.5 = 9.35 and 63.33 mL, TLG50% = 328.1, and TLG50% = 94.81, respectively.Conclusion Metabolic tumor volumes and TLGs in PET/CT are reliable diagnostic biomarkers. Using these parameters, more accurate preoperative diagnoses for CRC can be made.