NATURALLY ACQUIRED-IMMUNITY TO PLASMODIUM-FALCIPARUM
NATURALLY ACQUIRED-IMMUNITY TO PLASMODIUM-FALCIPARUM
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DOI：
10.1016/s0167-5699(05)80020-9
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发表时间：
1991-03-01
期刊：
影响因子：
--
通讯作者：
MARSH, K
中科院分区：
文献类型：
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作者：
DAY, KP;MARSH, K
疟疾感染会引发多种体液和细胞反应，其中大多数可能不具有保护性。对疟疾获得性免疫流行病学的讨论将集中在两个主要领域：第一，在流行环境中寄生虫与疾病之间的关系，以及在确定哪些反应在获得性保护性免疫中很重要方面受到的限制；第二，抗原多样性在宿主-寄生虫关系中的核心重要性。除非另有说明，否则全文的重点将放在人类主要病原体恶性疟原虫上。
Malaria infections induce multiple humoral and cellular responses, most of which are probably not protective. This discussion of the epidemiology of acquired immunity to malaria will concentrate on two main areas: first, the relationship between parasitism and disease in endemic settings and the contraints placed on determining which responses are important in acquired protective immunity; second, the central importance of antigenic diversity in the host-parasite relationship. The emphasis throughout, unless otherwise stated, will be on the major human pathogen Plasmodium falciparum.